Strain Report - Rat Genome Database

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Strain: Slc:ZUC-Leprfa-/-

Symbol: Slc:ZUC-Leprfa-/-
Strain: ZUC-Leprfa-/-
Substrain: Slc
Full Name: Zucker fatty rats
RGD ID: 12859278
Citation ID: RRID:RGD_12859278
Ontology ID: RS:0004403
Alleles: Leprfa;   Lepr
Previously known as: Slc:Zucker; ZF rats; Slc:ZUC-Leprfa ; Slc:ZUC-Leprfa
Type: outbred
Source: Japan SLC, Inc. (Hamamatsu, Japan)
Origin: The spontaneous mutation "obese" (Fatty) was found in the 13M rat stock of Sherman and Merck, by Doctor Lois Zucker, Harriet Bird Memorial Laboratory, Stow, Massachusetts 01775, USA, in 1961.This strain was maintained at Japan SLC, Inc. (Hamamatsu, Japan.)
Last Known Status: Unknown

Disease Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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References - curated
# Reference Title Reference Citation
1. Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. Gheni G, etal., J Diabetes Res. 2015;2015:261418. doi: 10.1155/2015/261418. Epub 2015 Apr 16.
2. Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats. Hiraoka-Yamamoto J, etal., Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):107-9.
3. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
4. A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat. Yokoi N, etal., J Diabetes Res. 2013;2013:103731. doi: 10.1155/2013/103731. Epub 2013 Feb 26.


Damaging Variants
Number of Damaging Variants
ZF (KyushuU) 1208

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Leprfa-var1 chr5 116389200 116389200 A C point_mutation mRatBN7.2
Leprfa-var1 chr5 120597857 120597857 A C point_mutation Rnor_6.0

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-07 Slc:ZUC-Leprfa-/-  Zucker fatty rats  Slc:ZUC-Leprfa  Zucker fatty rats  Symbol and/or name change 68913 APPROVED
2018-03-14 Slc:ZUC-Leprfa  Zucker fatty rats  Slc:ZUC-Leprfa   Zucker fatty rats  Symbol updated 68687 APPROVED
2017-04-14 Slc:ZUC-Leprfa   Zucker fatty rats  Slc:ZUC-Leprfa   Zucker rats  Name updated 68913 APPROVED