Strain Report - Rat Genome Database

Name: Slc:ZUC- Lepr fa-/-
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: Slc:ZUC-Lepr^fa-/-
Symbol:	Slc:ZUC-Lepr^fa-/-
Strain:	ZUC-Lepr^fa-/-
Substrain:	Slc
Full Name:	Zucker fatty rats
RGD ID:	12859278
Citation ID:	RRID:RGD_12859278
Ontology ID:	RS:0004403
Alleles:	Lepr^fa; Lepr
Previously known as:	Slc:Zucker; ZF rats; Slc:ZUC-Leprfa ; Slc:ZUC-Lepr^fa
Type:	outbred
Source:	Japan SLC, Inc. (Hamamatsu, Japan)
Origin:	The spontaneous mutation "obese" (Fatty) was found in the 13M rat stock of Sherman and Merck, by Doctor Lois Zucker, Harriet Bird Memorial Laboratory, Stow, Massachusetts 01775, USA, in 1961.This strain was maintained at Japan SLC, Inc. (Hamamatsu, Japan.)
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hypercholesterolemia (IAGP)

hyperinsulinism (IAGP)

Insulin Resistance (IAGP)

non-alcoholic steatohepatitis (IAGP)

obesity (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased catalase activity (IAGP)

decreased glutathione peroxidase activity (IAGP)

decreased superoxide dismutase level (IAGP)

decreased systemic arterial systolic blood pressure (IAGP)

impaired glucose tolerance (IAGP)

increased body weight (IAGP)

increased circulating alanine transaminase level (IAGP)

increased circulating cholesterol level (IAGP)

increased circulating free fatty acids level (IAGP)

increased circulating glucose level (IAGP)

increased circulating insulin level (IAGP)

increased circulating leptin level (IAGP)

increased circulating triglyceride level (IAGP)

increased epididymal fat pad weight (IAGP)

increased liver triglyceride level (IAGP)

increased liver weight (IAGP)

increased mesenteric fat pad weight (IAGP)

insulin resistance (IAGP)

liver inflammation (IAGP)

oxidative stress (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

body weight

blood glucose level

plasma insulin level

plasma triglyceride level

plasma triglyceride level area under curve

References

References - curated

#	Reference Title	Reference Citation
1.	Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat.	Gheni G, etal., J Diabetes Res. 2015;2015:261418. doi: 10.1155/2015/261418. Epub 2015 Apr 16.
2.	Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats.	Hiraoka-Yamamoto J, etal., Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):107-9.
3.	Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis.	Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
4.	A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat.	Yokoi N, etal., J Diabetes Res. 2013;2013:103731. doi: 10.1155/2013/103731. Epub 2013 Feb 26.

Region

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
ZF (KyushuU)		1208

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
Leprfa-var1	chr5	116389200	116389200	A	C	point_mutation	mRatBN7.2
Leprfa-var1	chr5	120597857	120597857	A	C	point_mutation	Rnor_6.0

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-02-07	Slc:ZUC-Lepr^fa-/-	Zucker fatty rats	Slc:ZUC-Lepr^fa	Zucker fatty rats	Symbol and/or name change	68913	APPROVED
2018-03-14	Slc:ZUC-Lepr^fa	Zucker fatty rats	Slc:ZUC-Lepr^fa	Zucker fatty rats	Symbol updated	68687	APPROVED
2017-04-14	Slc:ZUC-Lepr^fa	Zucker fatty rats	Slc:ZUC-Lepr^fa	Zucker rats	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Strain: Slc:ZUC-Lepr^fa-/-

Mammalian Phenotype

Related Phenotype Data for Term "Slc:ZUC-Leprfa-/-" (RS:0004403)

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Strain: Slc:ZUC-Leprfa-/-

Mammalian Phenotype

Related Phenotype Data for Term "Slc:ZUC-Leprfa-/-" (RS:0004403)

Strain: Slc:ZUC-Lepr^fa-/-