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Strain Registration

Strain: SD-Abcc8em1Cgen

Symbol: SD-Abcc8em1Cgen
Strain: SD-Abcc8em1
Substrain: Cgen
RGD ID: 127285409
Citation ID: RRID:RGD_127285409
Ontology ID: RS:0004958
Alleles: Abcc8em1Cgen
Also Known As: SD-Abcc8em1cgen; sur1-/- rat; SD-Abcc8^[em1Cgen]
Type: mutant
Available Source: Cyagen Biosciences Inc., Guangzhou, China
Origination: Department of Endocrinology, Shandong University, Jinan, China
Description: TALEN system targeting the rat Abcc8 (sulfonylurea receptor 1, SUR1 ) gene was injected into Crl:CD(SD) embryos. This strain carries a 16-bp deletion corresponding to CCT CAC GGG GCT TCTG compared with wild-type rats is homozygous. No Abcc8 protein was detected in the liver and muscle tissues.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81105,734,992 - 105,816,272RGD_MAPPER_PIPELINE
mRatBN7.2196,598,568 - 96,679,563RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01102,110,708 - 102,191,287RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01103,194,473 - 103,275,508RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4196,622,574 - 96,703,723RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat. Zhou X, etal., Br J Pharmacol. 2019 Feb;176(3):478-490. doi: 10.1111/bph.14553. Epub 2018 Dec 26.
2. aThe characteristics of glucose metabolism in the sulfonylurea receptor 1 knockout rat model. Zhou X, etal., Mol Med. 2019 Jan 7;25(1):2. doi: 10.1186/s10020-018-0067-9.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-06-22 SD-Abcc8em1Cgen    SD-Abcc8em1cgen    Symbol and/or name change 68913 APPROVED