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Strain Registration

Strain: SS-Shc1em5Mcwi

Symbol: SS-Shc1em5Mcwi
Strain: SS-Shc1em5
Substrain: Mcwi
RGD ID: 11553916
Citation ID: RRID:RGD_11553916
Ontology ID: RS:0004234
Alleles: Shc1em5Mcwi
Previously known as: SS-p66Shctm1(S36A)Mcwi; SS-Shc1em1(S36A)Mcwi; SS-Shc1em5Mcwi
Type: mutant
Source: MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
Origin: ZFN system was used to introduce a T>G transversion mutation in the Shc1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a substitution to generate S36A in Exon 2 of theShc1 gene.
Last Known Status: Live Animals (as of 2017-01-25)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,837,937 - 174,849,538RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02188,745,503 - 188,757,066RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02208,159,786 - 208,171,348RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42181,616,581 - 181,628,144RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
renal afferent arteriole diameter

References

References - curated
# Reference Title Reference Citation
1. p66Shc regulates renal vascular tone in hypertension-induced nephropathy. Miller B, etal., J Clin Invest. 2016 Jul 1;126(7):2533-46. doi: 10.1172/JCI75079. Epub 2016 Jun 6.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-25 SS-Shc1em5Mcwi    SS-Shc1em1(S36A)Mcwi    Symbol updated 68687 APPROVED
2017-01-25 SS-Shc1em5Mcwi    SS-Shc1em1(S36A)Mcwi    Symbol updated 68687 APPROVED