Strain Report - Rat Genome Database

Name: iNP- Npy em6Sage+/- /Iusm
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Strain Registration

General

Strain: iNP-Npy^em6Sage+/-/Iusm

Symbol:

iNP-Npy^em6Sage+/-/Iusm

Strain:

iNP-Npy^em6Sage+/-

Substrain:

Iusm

RGD ID:

11531104

Citation ID:

RRID:RGD_11531104

Ontology ID:

RS:0004215

Alleles:

Npy^em6Sage

Previously known as:

Npy+/-; NP/Iusm-Npyem6Sage+/- ; NP-Npy^em6Sage+/-/Iusm; NP/Iusm-Npy^em6Sage+/-

Type:

mutant

Source:

Department of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN 46202, USA

Origin:

The heterozygous ZFN mutant rats were produced by backcrossing mutant founders with iNP/Iusm. Genotyping of the offspring was carried out by PCR amplification of a 26-bp deleted fragment, including 6 bp in intron 1 and 20 bp in exon 2.

Genetic Status:

Heterozygous

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	78,881,294 - 78,888,495	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	4	79,557,856 - 79,565,059	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	4	144,233,753 - 144,240,956	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	4	78,038,013 - 78,045,187	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

alcohol preference (IAGP)

decreased body weight (IAGP)

increased alcohol consumption (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	A novel F8 -/- rat as a translational model of human hemophilia A.	Nielsen LN, etal., J Thromb Haemost. 2014 Aug;12(8):1274-82. doi: 10.1111/jth.12635.
2.	Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.	Qiu B, etal., J Genet Genomics. 2016 Jul 20;43(7):421-30. doi: 10.1016/j.jgg.2016.04.010. Epub 2016 Apr 29.

Region

Additional Information

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2023-05-02	iNP-Npy^em6Sage+/-/Iusm	NP-Npy^em6Sage+/-/Iusm	Symbol and/or name change	68913	APPROVED
2023-04-28	NP-Npy^em6Sage+/-/Iusm	NP/Iusm-Npy^em6Sage+/-	Symbol and/or name change	68913	APPROVED
2018-03-14	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Symbol updated	68687	APPROVED
2018-03-14	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Symbol updated	68687	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Name updated	68913	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Name updated	68913	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Name updated	68913	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Name updated	68913	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Name updated	68913	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Name updated	68913	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Symbol updated	68687	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Name updated	68913	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Symbol updated	68687	APPROVED
2016-08-26	NP/Iusm-Npy^em6Sage+/-	NP/Iusm-Npy^em6Sage+/-	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Create Name:

Description:

Send us a Message

Strain: iNP-Npyem6Sage+/-/Iusm

Mammalian Phenotype

Strain: iNP-Npy^em6Sage+/-/Iusm