Strain Report - Rat Genome Database

Name: SD- F8 em1Sage-/- /Novo
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SD-F8^em1Sage-/-/Novo

Symbol:

SD-F8^em1Sage-/-/Novo

Strain:

SD-F8^em1Sage-/SD-F8^em1Sage-

Substrain:

Novo

RGD ID:

11531091

Citation ID:

RRID:RGD_11531091

Ontology ID:

RS:0004212

Alleles:

F8^em1Sage

Previously known as:

F8-/-; SD/Novo-F8em1Sage-/-; SD/Novo-F8^em1Sage-/-

Type:

mutant

Source:

Novo Nordisk, Maaloev, Denmark

Origin:

The homozygous F8 mutant rats were produced by intercrossing the heterozygous ZFN mutants (SD-F8^em1Sage+/-/Novo) to produce homozygous and heterozygous offspring. Genotype of the homozygous offspring was confirmed by PCR amplification of the deletion fragment which caused a premature translation stop.

Genetic Status:

Homozygous

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	140,848 - 172,330	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	18	367,862 - 399,242	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	18	413,447 - 444,491	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	18	121,134 - 162,008	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

factor VIII deficiency (IMP)

hemarthrosis (IMP)

Hemophilic Arthropathy (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal bone remodeling (IMP)

abnormal hemostasis (IMP)

decreased circulating serum albumin level (IMP)

decreased circulating total protein level (IMP)

hemarthrosis (IMP)

hemorrhage (IMP)

increased bleeding time (IMP)

increased leukocyte cell number (IMP)

increased partial thromboplastin time (IMP)

joint inflammation (IMP)

thrombocytosis (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	A novel F8 -/- rat as a translational model of human hemophilia A.	Nielsen LN, etal., J Thromb Haemost. 2014 Aug;12(8):1274-82. doi: 10.1111/jth.12635.
2.	The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression.	Shi Q, etal., Blood Adv. 2020 Jan 14;4(1):55-65. doi: 10.1182/bloodadvances.2019000944.
3.	The F8(-/-) rat as a model of hemophilic arthropathy.	Sørensen KR, etal., J Thromb Haemost. 2016 Jun;14(6):1216-25. doi: 10.1111/jth.13328. Epub 2016 May 10.

Region

Additional Information

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2021-06-01	SD-F8^em1Sage-/-/Novo	SD/Novo-F8^em1Sage-/-	Symbol and/or name change	68913	APPROVED
2016-08-26	SD/Novo-F8^em1Sage-/-	SD/Novo-F8^em1Sage-/-	Name updated	68913	APPROVED
2016-08-26	SD/Novo-F8^em1Sage-/-	SD/Novo-F8^em1Sage-/-	Name updated	68913	APPROVED
2016-08-26	SD/Novo-F8^em1Sage-/-	SD/Novo-F8^em1Sage-/-	Name updated	68913	APPROVED
2016-08-26	SD/Novo-F8^em1Sage-/-	SD/Novo-F8^em1Sage-/-	Name updated	68913	APPROVED
2016-08-26	SD/Novo-F8^em1Sage-/-	SD/Novo-F8^em1Sage-/-	Name updated	68913	APPROVED
2016-08-26	SD/Novo-F8^em1Sage-/-	SD/Novo-F8^em1Sage-/-	Name updated	68913	APPROVED
2016-08-26	SD/Novo-F8^em1Sage-/-	SD/Novo-F8^em1Sage-/-	Name updated	68913	APPROVED
2016-08-26	SD/Novo-F8^em1Sage-/-	SD/Novo-F8^em1Sage-/-	Name updated	68913	APPROVED
2016-08-26	SD/Novo-F8^em1Sage-/-	SD/Novo-F8^em1Sage-/-	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SD-F8em1Sage-/-/Novo

Mammalian Phenotype

Strain: SD-F8^em1Sage-/-/Novo