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Strain Registration

Strain: F344tl

Symbol: F344tl
Strain: F344tl
Full Name: toothless (tl)
RGD ID: 11081177
Citation ID: RRID:RRRC_00749
Ontology ID: RS:0004188
Alleles: Csf1tl
Also Known As: F344-tl; F344tl; F344^[tl]
Type: mutant
Available Source: Rat Resource and Research Center
Origination: University of Massachusetts Medical School.
Description: A spontaneous tooth less mutation was maintained in inbred Fisher colony maintained at the University of Massachusetts Medical School. The homozygous mutant is a 10-bp insertion near the beginning of the open reading of the Csf1 gene that yields a truncated, nonfunctional protein and an early stop codon.
Genetic Status: Homozygous
Last Known Status: Unknown
Research Usage skeletal and osteoclast biology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,396,104 - 195,396,105RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02210,550,359 - 210,550,360RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02229,989,430 - 230,017,945RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42203,292,765 - 203,307,968RGD_MAPPER_PIPELINERGSC3.4





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Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification. Van Wesenbeeck L, etal., Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14303-8.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Csf1tl-var1 chr2 195396104 195396105 - GCGCCCCGCG insertion mRatBN7.2
Csf1tl-var1 chr2 210550359 210550360 - GCGCCCCGCG insertion Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics No tooth eruption, virtually no marrow spaces, skeletal phenotype is partially rescued by injections of CSF-1 (M-CSF). 2292495
strain_other Severe, osteoclast-poor osteopetrosis in homozygous mutants. Heterozygotes unaffected. 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-31 F344tl  toothless (tl)  F344-tl  toothless (tl)  Symbol updated 68687 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00749 RGD