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Strain: SD-Esr2em1Soar

Symbol: SD-Esr2em1Soar
Strain: SD-Esr2em1
Substrain: Soar
RGD ID: 11081149
Citation ID: RRID:RRRC_00742
Ontology ID: RS:0004184
Alleles: Esr2em1Soar
Previously known as: SD-Esr2em1Soar; Esr-2 dE4
Type: mutant
Source: Rat Resource and Research Center
Origin: Zinc finger nuclease targeting of exon 4 of the rat estrogen receptor-2 gene resulting in the deletion of exon 4
Genetic Status: Heterozygous
Coat Color: white
Last Known Status: Unknown
Research Usage reproduction
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,858,438 - 94,909,630RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0699,163,953 - 99,214,711RGD_MAPPER_PIPELINERnor6.0
Rnor_5.06108,576,398 - 108,626,196RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4698,691,167 - 98,775,299RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. ESR2 regulates granulosa cell genes essential for follicle maturation and ovulation. Khristi V, etal., Mol Cell Endocrinol. 2018 Oct 15;474:214-226. doi: 10.1016/j.mce.2018.03.012. Epub 2018 Mar 24.
2. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility. Rumi MAK, etal., Endocrinology. 2017 Jul 1;158(7):2330-2343. doi: 10.1210/en.2016-1916.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other background strain Hsd:SD 2292495
strain_other The mutation generates a natural Esr2 variant that is devoid of DNA binding activity. 2292495
strain_reproduction Randomly breed heterozygous males and heterozygous females 2292495
Database Acc Id Source(s)
RRRC RRRC:00742 RGD