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Strain Registration

Strain: F344-TyrCKitH/Kyo

Symbol: F344-TyrCKitH/Kyo
Strain: F344-TyrCKitH
Substrain: Kyo
RGD ID: 11040971
Citation ID: RRID:RGD_11040971
Ontology ID: RS:0004152
Alleles: Tyr;   Kit
Also Known As: Black Fischer; NBRP Rat No: 0768; F344-TyrCKitH/Kyo; F344-Tyr^[C]Kit^[H]/Kyo
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: 1) point mutation in the exon 2 (896G>A, p.R229H) of Tyrosinase (Tyr) gene (albino phenotype) and 2) retrotransposon insertion (7-bp) in kit gene (hooded phenotype) were targeted by CRISPR/Cas9 system using ssODN. The rat coat colour phenotype was changed from white to black. Background strain: F344/Stm
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2017-07-17)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21432,547,459 - 32,624,694RGD_MAPPER_PIPELINEmRatBN7.2
mRatBN7.21141,115,036 - 141,210,207RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01435,072,131 - 35,149,638RGD_MAPPER_PIPELINERnor6.0
Rnor_6.01151,012,598 - 151,106,802RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01157,322,968 - 157,416,594RGD_MAPPER_PIPELINERnor5.0
Rnor_5.01434,901,860 - 34,979,384RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41434,906,043 - 34,984,819RGD_MAPPER_PIPELINERGSC3.4
RGSC_v3.41143,641,257 - 143,746,315RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR-Cas platform. Yoshimi K, etal., Nat Commun. 2014 Jun 26;5:4240. doi: 10.1038/ncomms5240.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Black coat color (genetic background: F344/Stm) 1302502
strain_reproduction homozygous condition (black color) 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-18 F344-TyrCKitH/Kyo    F344-TyrC KitH/Kyo    Symbol updated 68687 APPROVED
2016-03-18 F344-TyrCKitH/Kyo    F344-TyrC KitH/Kyo    Name updated 68913 APPROVED
2016-03-18 F344-TyrCKitH/Kyo    F344-TyrC KitH/Kyo    Symbol updated 68687 APPROVED
2016-03-18 F344-TyrCKitH/Kyo    F344-TyrC KitH/Kyo    Name updated 68913 APPROVED