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Strain: LEA-Tp53tm1(AmCyan1)Ncco

Symbol: LEA-Tp53tm1(AmCyan1)Ncco
Strain: LEA-Tp53tm1(AmCyan1)Ncco
Substrain: Ncco
RGD ID: 11040954
Citation ID: RRID:RGD_11040954
Ontology ID: RS:0004143
Also Known As: LEA-Tp53tm1(AmCyan1)Ncco; p53 mutant rat; LEA-p53-KO(AmCyan1/IRES/Neo)3NCCRI; NBRP Rat No: 0718; LEA-Tp53^[tm1(AmCyan1)Ncco]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: LEA rats were provided from Kyoto Bioresource Center in 2006. Then LEA rat ES cells having Oct4-Venus gene and Oct4-Venus Tg rat strain (LEA-Tg(Pou5f1-YFP*)3Ncco) were established.
Last Known Status: Cryopreserved Embryo


References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics AmCyan1 expression under CAG-promoter and deletion of p53 gene expression. Almost all p53 heterozygous rats die of tumor within one year of age. 1302502
strain_other ES cells were established from Oct4-Venus Tg rat, p53 heterozygous-ES cells were made by gene targeting method and finally p53-heterozygous rat strain (LEA-Tp53tm1(AmCyan1)Ncco) was established by germline transmission. Deposited p53-heterozygous rats do not have Oct4-Venus. 1302502
strain_reproduction mating between heterozygous rats 1302502