Strain Report - Rat Genome Database

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Strain: TM-Prkdcem4KyoIl2rgem5Kyo

Symbol: TM-Prkdcem4KyoIl2rgem5Kyo
Strain: TM-Prkdcem4Il2rgem5
Substrain: Kyo
RGD ID: 11040950
Citation ID: RRID:RGD_11040950
Ontology ID: RS:0004141
Alleles: Il2rg;   Il2rgem5Kyo;   Prkdcem4Kyo;   Prkdc
Also known as: TM-Prkdcem4KyoIl2rgem5Kyo; TM-DSCID; NBRP Rat No: 0648
Type: mutant
Source: National BioResource Project for the Rat in Japan
Origin: This strain was established by Zinc-finger nucleases (ZFNs) method causing 20-bp deletion in the exon1 of Prkdc gene and a 653-bp deletion Il2rg gene. Background strain: TM/Kyo
Coat Color: Albino
Last Known Status: Cryopreserved Sperm (as of 2017-07-12)
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21185,040,790 - 85,258,357RGD_MAPPER_PIPELINEmRatBN7.2
mRatBN7.2X66,395,330 - 66,399,026RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X71,165,378 - 71,169,078RGD_MAPPER_PIPELINERnor6.0
Rnor_6.01189,293,547 - 89,510,948RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01192,347,175 - 92,565,022RGD_MAPPER_PIPELINERnor5.0
Rnor_5.0X72,017,856 - 72,021,516RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41186,951,420 - 87,169,229RGD_MAPPER_PIPELINERGSC3.4
RGSC_v3.4X89,342,055 - 89,345,715RGD_MAPPER_PIPELINERGSC3.4


References - curated
1. Personal Communication with NBRP
2. RGD Automated Pipelines


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This strain shows severe combined immunodeficiency_SCID_and growth retardation caused by a 20-bp deletion in the exon 1 of Prkdc gene and a 653-bp deletion in Il2rg gene 1302502
strain_reproduction maintained by mating between Il2rg-homozygous/Prkdc-heterozygous rats 1302502