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Strain Registration

Strain: WI-Foxn1em2Nips

Symbol: WI-Foxn1em2Nips
Strain: WI-Foxn1em2
Substrain: Nips
RGD ID: 10053601
Citation ID: RRID:RGD_10053601
Ontology ID: RS:0003949
Alleles: Foxn1em2Nips
Also Known As: WI-Foxn1em2Nips; WI-Foxn1^[em2Nips]
Type: mutant
Available Source: Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN
Description: Foxn1 mutation was induced by injecting pX330 expressing Cas9 and sgRNA targeting the sequence GACTGGAGGGCGAACCCCAA into Crlj:WI rat embryos. The resulting mutation is a 60-bp frameshift deletion in exon 1 (del 46-105).
Coat Color: Albino
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81063,749,461 - 63,778,468RGD_MAPPER_PIPELINE
mRatBN7.21063,251,400 - 63,273,710RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01065,621,142 - 65,634,666RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01066,004,940 - 66,030,134RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41064,243,323 - 64,256,847RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. Hypomorphic phenotype of Foxn1 gene-modified rats by CRISPR/Cas9 system. Goto T, etal., Transgenic Res. 2016 Aug;25(4):533-44. doi: 10.1007/s11248-016-9941-9. Epub 2016 Mar 2.
2. Data registered by National Institute for Physiological Sciences, JAPAN Personal communication between Dr. Masumi Hirabayashi and RGD curators

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics thymus/T-cell-deficiency 7411635
strain_reproduction Lethal at Day5-6 7411635

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 WI-Foxn1em2Nips    WI-Foxn1em2Nips    Symbol updated 68687 APPROVED
2016-03-16 WI-Foxn1em2Nips    WI-Foxn1em2Nips    Name updated 68913 APPROVED
2016-03-16 WI-Foxn1em2Nips    WI-Foxn1em2Nips    Symbol updated 68687 APPROVED
2016-03-16 WI-Foxn1em2Nips    WI-Foxn1em2Nips    Name updated 68913 APPROVED