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Strain Registration

Strain: F344-Cacna1agryScn1am1Kyo/Okym

Symbol: F344-Cacna1agryScn1am1Kyo/Okym
Strain: F344-Cacna1agryScn1am1Kyo
Substrain: Okym
RGD ID: 10045591
Citation ID: RRID:RGD_10045591
Ontology ID: RS:0003930
Alleles: Scn1am1Kyo;   Cacna1agry
Also Known As: F344.GRY-Cacna1agry/Okym; M251K-Cacna1a mutation; F344-Scn1am1Kyo.GRY-Cacna1agry/Okym; NBRP Rat No: 0756; F344.GRY-Cacna1agryScn1am1Kyo/Okym; F344-Scn1am1Kyo.GRY-Cacna1agry/Okym; F344-Cacna1a^[gry]Scn1a^[m1Kyo]/Okym
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: GRY/Idr (GRY/Idr has the M251K mutation in the Cacna1a gene) was backcrossed to F344/NSlc, and then crossed to HISS rat (HISS rat has the N1417H mutation in the Scn1a gene) to generate Scn1a/Cacna1a double mutant rats.
Coat Color: Albino
Inbred Generations: F23
Last Known Status: Cryopreserved Sperm (as of 2017-05-05)
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,520,741 - 23,819,971RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01925,453,236 - 25,749,550RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01936,502,533 - 36,727,039RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41925,188,170 - 25,424,495RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (Cacna1a)
Rat AssemblyChrPosition (strand)Source
GRCr81940,425,560 - 40,724,810 (-)NCBI
mRatBN7.21923,520,741 - 23,819,971 (-)NCBI
mRatBN7.2 Ensembl1923,520,741 - 23,823,225 (-)Ensembl
UTH_Rnor_SHR_Utx1930,343,968 - 30,567,151 (-)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.01930,998,339 - 31,221,535 (-)NCBI
UTH_Rnor_WKY_Bbb_1.01933,221,032 - 33,444,209 (-)NCBI
Rnor_6.01925,453,236 - 25,749,550 (+)NCBI
Rnor_6.0 Ensembl1925,526,751 - 25,749,550 (+)Ensembl
Rnor_5.01936,502,533 - 36,727,039 (+)NCBI
RGSC_v3.41925,188,170 - 25,424,495 (-)NCBI
RGSC_v3.11925,194,294 - 25,429,321 (-)NCBI
Celera1923,074,249 - 23,295,970 (-)NCBI
Cytogenetic Map19q11NCBI

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics The homozygous rats show absence epilepsy and cerebellar ataxia. No significant physical abnormality is observed in the heterozygous rats. 1302502
strain_reproduction Mating between heterozygous male and heterozygous female; Homozygous female rats tend to neglect their pups. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-21 F344-Cacna1agryScn1am1Kyo/Okym    F344.GRY-Cacna1agryScn1am1Kyo/Okym    Symbol and/or name change 68913 APPROVED
2021-07-20 F344.GRY-Cacna1agryScn1am1Kyo/Okym    F344-Scn1am1Kyo.GRY-Cacna1agry/Okym    Symbol and/or name change 68913 APPROVED
2017-05-05 F344-Scn1am1Kyo.GRY-Cacna1agry/Okym    F344.GRY-Cacna1agry/Okym    Symbol updated 68687 APPROVED
2017-05-05 F344-Scn1am1Kyo.GRY-Cacna1agry/Okym    F344.GRY-Cacna1agry/Okym    Symbol updated 68687 APPROVED