Strain Report - Rat Genome Database
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Strain: SS/Jr

Symbol: SS/Jr
Strain: SS
Substrain: Jr
Full Name: Salt Sensitive
RGD ID: 10041
RRID: RGD_10041
Ontology ID: RS:0000817
Alleles: Hmox1
Also known as: SS/jrctr; RRRC:0055; MDC-03-13; SS/JrMco
Type: inbred
Source: Dr. John P. Rapp, Medical College of Ohio, USA, Rat Resource and Research Center
Origin: Strain originated from a colony of Sprague-Dawley outbred rats developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for sensitivity to salt-induced hypertension (Dahl et al 1962a,b, Rapp 1982)
Genetic Markers: c.
Coat Color: Albino
Inbred Generations: F42.
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm





Disease Annotations     Click to see Annotation Detail View


Phenotype Values via Phenominer     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
mean arterial blood pressure
body weight
hematocrit
plasma glucose level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart left ventricle wet weight
calculated heart weight
heart weight to body weight ratio
both kidneys wet weight
calculated kidney weight
ejection fraction
heart left ventricle posterior wall thickness
pulse pressure
both kidneys wet weight to body weight ratio
serum triglyceride level
serum total cholesterol level
body weight gain
blood uric acid level
hemoglobin concentration
heart left ventricle weight to body weight ratio
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma triglyceride level
serum albumin level
plasma total cholesterol level
plasma urea nitrogen level
absolute change in systolic blood pressure
blood vessel contractile force measurement
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
percent change in heart rate
urine total protein excretion rate
urine albumin excretion rate
heart right ventricle weight to body weight ratio
artery wall thickness to artery inner diameter ratio
heart left ventricular end-diastolic diameter
heart left ventricle end-systolic diameter
heart left ventricle fractional shortening
heart left ventricle anterior wall thickness
heart ventricle septal wall thickness
heart left ventricle relative wall thickness
velocity of circumferential fiber shortening
heart left ventricle end-diastolic area
heart left ventricle end-systolic area
age at time of death
cerebrospinal fluid chloride level
red blood cell Na+/K+ ATPase activity
peak aortic velocity
heart isovolumetric relaxation time
heart left atrium end-systolic diameter
heart left atrium end-diastolic diameter
heart left atrium fractional shortening
aorta smooth muscle cell count per unit vessel length
heart left ventricle deoxyribonucleic acid content to body weight ratio
heart right ventricle deoxyribonucleic acid content to body weight ratio
receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio
logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50)
tibia midshaft total cross-sectional area
tibia midshaft endosteal cross-sectional area
percent change in mean arterial blood pressure
change in heart rate to change in mean arterial blood pressure ratio
maximum change in heart rate to change in mean arterial blood pressure ratio
bone section total volume
bone section mineralized tissue volume
bone section mineralized tissue surface area
bone section volume fraction
bone section surface density
bone section structure model index
bone section connectivity density
bone section trabecular thickness
bone section trabecular separation
tibia midshaft cortical thickness

References

References - curated
1. Cicila GT, etal., J Hypertens 1994 Jun;12(6):643-51
2. Cicila GT, etal., Mamm Genome 1997 Dec;8(12):896-902.
3. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
4. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
5. Deng AY, etal., J Clin Invest 1994 Jun;93(6):2701-9
6. Deng AY, etal., J Hypertens. 2008 Oct;26(10):1935-1943.
7. Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
8. Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
9. Festing, MFW, Personal Communication Update, Feb-2000
10. Garrett MR and Rapp JP, Physiol Genomics 2002 Feb 28;8(2):81-6.
11. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
12. Garrett MR, etal., J Am Soc Nephrol 2003 May;14(5):1175-87.
13. Garrett MR, etal., J Hypertens 2002 Dec;20(12):2399-406.
14. Garrett MR, etal., Physiol Genomics 2000 Jun 29;3(1):33-8.
15. Ginn DI, etal., J Hypertens 1993 May;11(5):477-81.
16. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
17. Kato N, etal., Mamm Genome 1999 Mar;10(3):259-65.
18. Kubisch HM, etal., Hypertension. 1998 Jan;31(1 Pt 2):540-5.
19. Kumarasamy S, etal., Mamm Genome. 2010 May 5.
20. Margo CE, etal., Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1422-8.
21. Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.
22. Palijan A, etal., Hypertension 2003 Oct;42(4):515-22. Epub 2003 Aug 25
23. Personal Communication with Rat Resource & Research Center
24. Pravenec M and Petretto E, Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):393-7.
25. Rapp JP and Deng AY, Hypertension 1995 Jun;25(6):1121-8.
26. Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
27. RGD Automated Pipelines
28. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
29. Schulz A and Kreutz R, Hypertens Res. 2012 Jul;35(7):675-94. doi: 10.1038/hr.2012.77. Epub 2012 May 31.
30. St. Lezin EM, etal., J Clin Invest 1996 Jan 15;97(2):522-7
31. Zhang QY, etal., Mamm Genome 1997 Sep;8(9):636-41

Region

Strain QTL Data
Symbol Name Trait
Bp10 Blood pressure QTL 10 arterial blood pressure trait   (VT:2000000)    
Bp115 Blood pressure QTL 115 arterial blood pressure trait   (VT:2000000)    
Bp116 Blood pressure QTL 116 arterial blood pressure trait   (VT:2000000)    
Bp12 Blood pressure QTL 12 arterial blood pressure trait   (VT:2000000)    
Bp158 Blood pressure QTL 158 arterial blood pressure trait   (VT:2000000)    
Bp167 Blood pressure QTL 167 arterial blood pressure trait   (VT:2000000)    
Bp168 Blood pressure QTL 168 blood pressure trait   (VT:0000183)    
Bp24 Blood pressure QTL 24 arterial blood pressure trait   (VT:2000000)    
Bp25 Blood pressure QTL 25 arterial blood pressure trait   (VT:2000000)    
Bp27 Blood pressure QTL 27 arterial blood pressure trait   (VT:2000000)    
Bp30 Blood pressure QTL 30 arterial blood pressure trait   (VT:2000000)    
Bp34 Blood pressure QTL 34 arterial blood pressure trait   (VT:2000000)    
Bp36 Blood pressure QTL 36 blood pressure trait   (VT:0000183)    
Bp37 Blood pressure QTL 37 blood pressure trait   (VT:0000183)    
Bp38 Blood pressure QTL 38 arterial blood pressure trait   (VT:2000000)    
Bp39 Blood pressure QTL 39 arterial blood pressure trait   (VT:2000000)    
Bp40 Blood pressure QTL 40 blood pressure trait   (VT:0000183)    
Bp41 Blood pressure QTL 41 blood pressure trait   (VT:0000183)    
Bp61 Blood pressure QTL 61 arterial blood pressure trait   (VT:2000000)    
Bp62 Blood pressure QTL 62 arterial blood pressure trait   (VT:2000000)    
Bp7 Blood pressure QTL 7 arterial blood pressure trait   (VT:2000000)    
Bp76 Blood pressure QTL 76 arterial blood pressure trait   (VT:2000000)    
Bp8 Blood pressure QTL 8 arterial blood pressure trait   (VT:2000000)    
Bp81 Blood pressure QTL 81 arterial blood pressure trait   (VT:2000000)    
Bp82 Blood pressure QTL 82 arterial blood pressure trait   (VT:2000000)    
Bp83 Blood pressure QTL 83 arterial blood pressure trait   (VT:2000000)    
Bp9 Blood pressure QTL 9 arterial blood pressure trait   (VT:2000000)    
Bp92 Blood pressure QTL 92 arterial blood pressure trait   (VT:2000000)    
Bp99 Blood pressure QTL 99 arterial blood pressure trait   (VT:2000000)    
Bw108 Body weight QTL 108 body mass   (VT:0001259)    
Bw109 Body weight QTL 109 body mass   (VT:0001259)    
Bw110 Body weight QTL 110 body mass   (VT:0001259)    
Bw111 Body weight QTL 111 body mass   (VT:0001259)    
Bw8 Body weight QTL 8 body mass   (VT:0001259)    
Bw9 Body weight QTL 9 body mass   (VT:0001259)    
Cm1 Cardiac mass QTL 1 heart mass   (VT:0007028)    
Cm13 Cardiac mass QTL 13 heart mass   (VT:0007028)    
Cm14 Cardiac mass QTL 14 heart mass   (VT:0007028)    
Cm28 Cardiac mass QTL 28 heart mass   (VT:0007028)    
Cm50 Cardiac mass QTL 50 heart mass   (VT:0007028)    
Cm51 Cardiac mass QTL 51 heart mass   (VT:0007028)    
Cm52 Cardiac mass QTL 52 heart mass   (VT:0007028)    
Cm53 Cardiac mass QTL 53 heart mass   (VT:0007028)    
Kidm29 Kidney mass QTL 29 kidney mass   (VT:0002707)    
Klgr1 Kidney lesion grade QTL 1 kidney morphology trait   (VT:0002135)    
Pur4 Proteinuria QTL 4 total urine protein amount   (VT:0000032)    
Pur5 Proteinuria QTL 5 total urine protein amount   (VT:0000032)    
Pur6 Proteinuria QTL 6 total urine protein amount   (VT:0000032)    
Uae13 Urinary albumin excretion QTL 13 urine albumin amount   (VT:0002871)    
Uae14 Urinary albumin excretion QTL 14 urine albumin amount   (VT:0002871)    
Uae15 Urinary albumin excretion QTL 15 urine albumin amount   (VT:0002871)    
Uae16 Urinary albumin excretion QTL 16 urine albumin amount   (VT:0002871)    
Uae17 Urinary albumin excretion QTL 17 urine albumin amount   (VT:0002871)    
Uae18 Urinary albumin excretion QTL 18 urine albumin amount   (VT:0002871)    
Uae19 Urinary albumin excretion QTL 19 urine albumin amount   (VT:0002871)    
Uae30 Urinary albumin excretion QTL 30 urine albumin amount   (VT:0002871)    
Uae31 Urinary albumin excretion QTL 31 urine albumin amount   (VT:0002871)    
Uae39 Urinary albumin excretion QTL 39 urine albumin amount   (VT:0002871)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
SS/Jr (ICL) 634
SS/Jr (KNAW) 689
SS/Jr (RGD) 770


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other These are genetically different from SR/Jr, according to the restriction fragment length polymorphism (RFLP) there is a mutation in every 1532 base pairs. 1358976
strain_other According to RFPLP analysis, the degree of variation between SS/Jr and Albino Surgery rats is 23% and between SS/Jr and BN rats is 71% 1358976
strain_other Mitochondrial DNA is 16,309 bp in size 2325144
strain_reproduction Produce one litter of about 8 pups, but second litter is small due to hypertension 1004
strain_reproduction Produce one litter of about 8 pups, but second litter is small due to hypertension 634612