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Strain Registration

Strain: SS/Jr

Symbol: SS/Jr
Strain: SS
Substrain: Jr
Full Name: Salt Sensitive
RGD ID: 10041
Citation ID: RRID:RRRC_00055
Ontology ID: RS:0000817
Alleles: Hmox1
Previously known as: SS/jrctr; MDC-03-13; SS/JrMco
Type: inbred
Source: Dr. John P. Rapp, Medical College of Ohio, USA, Rat Resource and Research Center
Origin: Strain originated from a colony of Sprague-Dawley outbred rats developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for sensitivity to salt-induced hypertension (Dahl et al 1962a,b, Rapp 1982)
Genetic Markers: c
Coat Color: Albino
Inbred Generations: F42.
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm





Disease Annotations     Click to see Annotation Detail View

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Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
heart weight
hematocrit
plasma glucose level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart left ventricle wet weight
calculated heart weight
heart weight to body weight ratio
both kidneys wet weight
calculated kidney weight
ejection fraction
heart left ventricle posterior wall thickness
respiration rate
pulse pressure
both kidneys wet weight to body weight ratio
serum triglyceride level
serum total cholesterol level
body weight gain
blood uric acid level
heart left ventricle weight to body weight ratio
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma triglyceride level
serum albumin level
plasma total cholesterol level
plasma urea nitrogen level
left ventricular end-diastolic blood pressure
absolute change in systolic blood pressure
single kidney wet weight to body weight ratio
blood vessel contractile force measurement
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
percent change in heart rate
urine total protein excretion rate
urine albumin excretion rate
heart right ventricle weight to body weight ratio
heart left ventricle end-diastolic diameter
heart left ventricle end-systolic diameter
heart left ventricle fractional shortening
heart left ventricle anterior wall thickness
heart ventricle septal wall thickness
heart left ventricle relative wall thickness
velocity of circumferential fiber shortening
heart left ventricle end-diastolic area
heart left ventricle end-systolic area
age at time of death
cerebrospinal fluid chloride level
artery neointimal hyperplastic lesion area
artery neointimal hyperplastic lesion area to total wall area ratio
peak aortic velocity
heart isovolumetric relaxation time
heart left atrium end-systolic diameter
heart left atrium end-diastolic diameter
heart left atrium fractional shortening
aorta smooth muscle cell count per unit vessel length
heart left ventricle deoxyribonucleic acid content to body weight ratio
heart right ventricle deoxyribonucleic acid content to body weight ratio
receptor-dependent blood vessel maximum contractile force to receptor-independent blood vessel maximum contractile force ratio
logarithm of the concentration of angiotensin II at which the force of blood vessel contraction is half the maximum value (Log EC50)
tibia midshaft total cross-sectional area
tibia midshaft endosteal cross-sectional area
maximum rate of positive change in left ventricular blood pressure
percent change in mean arterial blood pressure
change in heart rate to change in mean arterial blood pressure ratio
maximum change in heart rate to change in mean arterial blood pressure ratio
artery wall thickness to artery total diameter ratio
bone section total volume
bone section mineralized tissue volume
bone section mineralized tissue surface area
bone section volume fraction
bone section surface density
bone section connectivity density
bone section trabecular thickness
bone section trabecular separation
tibia midshaft cortical thickness
maximum rate of positive change in left ventricular blood pressure to left ventricular systolic blood pressure ratio
minimum rate of positive change in left ventricular blood pressure
artery neointimal hyperplastic lesion area including tunica media
ouabain-sensitive red blood cell Na+ export rate
ouabain-sensitive red blood cell K+ import rate
bumetanide-sensitive red blood cell Na+ export rate
bumetanide-sensitive red blood cell K+ import rate
ouabain- and bumetanide-resistant red blood cell Na+ import rate
ouabain- and bumetanide-resistant red blood cell K+ import rate

References

References - curated
# Reference Title Reference Citation
1. Cardiac pathways distinguish two epistatic modules enacting BP quantitative trait loci and candidate gene analysis. Chauvet C, etal., Hypertens Res. 2009 Jul;32(7):631-7. doi: 10.1038/hr.2009.70. Epub 2009 May 22.
2. alpha-Kinase 2 is a novel candidate gene for inherited hypertension in Dahl rats. Chauvet C, etal., J Hypertens. 2011 Jul;29(7):1320-6. doi: 10.1097/HJH.0b013e32834705e4.
3. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. Cicila GT, etal., J Hypertens 1994 Jun;12(6):643-51
4. Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats. Cicila GT, etal., Mamm Genome 1997 Dec;8(12):896-902.
5. Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats. Cicila GT, etal., Mamm Genome 1999 Feb;10(2):112-6.
6. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
7. Evaluation of the angiotensin II receptor AT1B gene as a candidate gene for blood pressure. Deng AY and Rapp JP, J Hypertens 1994 Sep;12(9):1001-6.
8. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
9. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. Deng AY, etal., J Clin Invest 1994 Jun;93(6):2701-9
10. Distinct genomic replacements from Lewis correct diastolic dysfunction, attenuate hypertension, and reduce left ventricular hypertrophy in Dahl salt-sensitive rats. Deng AY, etal., J Hypertens. 2008 Oct;26(10):1935-1943.
11. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
12. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
13. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
14. Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats. Garrett MR and Rapp JP, Physiol Genomics 2002 Feb 28;8(2):81-6.
15. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
16. Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. Garrett MR, etal., J Am Soc Nephrol 2003 May;14(5):1175-87.
17. Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains. Garrett MR, etal., J Hypertens 2002 Dec;20(12):2399-406.
18. Blood pressure QTL that differentiate dahl salt-sensitive and spontaneously hypertensive rats Garrett MR, etal., Physiol Genomics 2000 Jun 29;3(1):33-8.
19. Genetic linkage of urinary albumin excretion in Dahl salt-sensitive rats: influence of dietary salt and confirmation using congenic strains. Garrett MR, etal., Physiol Genomics. 2006 Mar 13;25(1):39-49.
20. Estimate of the genetic divergence between inbred Dahl salt-sensitive and salt-resistant rats. Ginn DI, etal., J Hypertens 1993 May;11(5):477-81.
21. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
22. Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats. Kato N, etal., Mamm Genome 1999 Mar;10(3):259-65.
23. Modulation of blood pressure in the Dahl SS/jr rat by embryo transfer. Kubisch HM, etal., Hypertension. 1998 Jan;31(1 Pt 2):540-5.
24. Mitochondrial polymorphisms in rat genetic models of hypertension. Kumarasamy S, etal., Mamm Genome. 2010 May 5.
25. Hereditary cataracts in the John Rapp inbred strain of Dahl salt-sensitive rat. Margo CE, etal., Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1422-8.
26. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Moreno C, etal., Physiol Genomics 2003 Nov 11;15(3):243-57. Epub 2003 Oct 07.
27. Comprehensive Congenic Coverage Revealing Multiple Blood Pressure Quantitative Trait Loci on Dahl Rat Chromosome 10. Palijan A, etal., Hypertension 2003 Oct;42(4):515-22. Epub 2003 Aug 25
28. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
29. Early onset albuminuria in Dahl rats is a polygenetic trait that is independent from salt loading. Poyan Mehr A, etal., Physiol Genomics 2003 Aug 15;14(3):209-16.
30. Insight into the genetics of hypertension, a core component of the metabolic syndrome. Pravenec M and Petretto E, Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):393-7.
31. Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Identifying the genes for genetic hypertension. Rapp JP and Deng AY, Hypertension 1995 Jun;25(6):1121-8.
32. Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
33. RGD Strain RSO annotation pipeline RGD Automated Pipelines
34. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
35. Mapping genetic determinants of kidney damage in rat models. Schulz A and Kreutz R, Hypertens Res. 2012 Jul;35(7):675-94. doi: 10.1038/hr.2012.77. Epub 2012 May 31.
36. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. St. Lezin EM, etal., J Clin Invest 1996 Jan 15;97(2):522-7
37. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Zhang QY, etal., Mamm Genome 1997 Sep;8(9):636-41

Region

Strain QTL Data
Symbol Name Trait
Bp10 Blood pressure QTL 10 arterial blood pressure trait   (VT:2000000)    
Bp115 Blood pressure QTL 115 arterial blood pressure trait   (VT:2000000)    
Bp116 Blood pressure QTL 116 arterial blood pressure trait   (VT:2000000)    
Bp12 Blood pressure QTL 12 arterial blood pressure trait   (VT:2000000)    
Bp158 Blood pressure QTL 158 arterial blood pressure trait   (VT:2000000)    
Bp167 Blood pressure QTL 167 arterial blood pressure trait   (VT:2000000)    
Bp168 Blood pressure QTL 168 blood pressure trait   (VT:0000183)    
Bp24 Blood pressure QTL 24 arterial blood pressure trait   (VT:2000000)    
Bp25 Blood pressure QTL 25 arterial blood pressure trait   (VT:2000000)    
Bp27 Blood pressure QTL 27 arterial blood pressure trait   (VT:2000000)    
Bp30 Blood pressure QTL 30 arterial blood pressure trait   (VT:2000000)    
Bp34 Blood pressure QTL 34 arterial blood pressure trait   (VT:2000000)    
Bp36 Blood pressure QTL 36 blood pressure trait   (VT:0000183)    
Bp37 Blood pressure QTL 37 blood pressure trait   (VT:0000183)    
Bp38 Blood pressure QTL 38 arterial blood pressure trait   (VT:2000000)    
Bp39 Blood pressure QTL 39 arterial blood pressure trait   (VT:2000000)    
Bp40 Blood pressure QTL 40 blood pressure trait   (VT:0000183)    
Bp41 Blood pressure QTL 41 blood pressure trait   (VT:0000183)    
Bp61 Blood pressure QTL 61 arterial blood pressure trait   (VT:2000000)    
Bp62 Blood pressure QTL 62 arterial blood pressure trait   (VT:2000000)    
Bp7 Blood pressure QTL 7 arterial blood pressure trait   (VT:2000000)    
Bp76 Blood pressure QTL 76 arterial blood pressure trait   (VT:2000000)    
Bp8 Blood pressure QTL 8 arterial blood pressure trait   (VT:2000000)    
Bp81 Blood pressure QTL 81 arterial blood pressure trait   (VT:2000000)    
Bp82 Blood pressure QTL 82 arterial blood pressure trait   (VT:2000000)    
Bp83 Blood pressure QTL 83 arterial blood pressure trait   (VT:2000000)    
Bp9 Blood pressure QTL 9 arterial blood pressure trait   (VT:2000000)    
Bp92 Blood pressure QTL 92 arterial blood pressure trait   (VT:2000000)    
Bp99 Blood pressure QTL 99 arterial blood pressure trait   (VT:2000000)    
Bw108 Body weight QTL 108 body mass   (VT:0001259)    
Bw109 Body weight QTL 109 body mass   (VT:0001259)    
Bw110 Body weight QTL 110 body mass   (VT:0001259)    
Bw111 Body weight QTL 111 body mass   (VT:0001259)    
Bw8 Body weight QTL 8 body mass   (VT:0001259)    
Bw9 Body weight QTL 9 body mass   (VT:0001259)    
Cm1 Cardiac mass QTL 1 heart mass   (VT:0007028)    
Cm13 Cardiac mass QTL 13 heart mass   (VT:0007028)    
Cm14 Cardiac mass QTL 14 heart mass   (VT:0007028)    
Cm28 Cardiac mass QTL 28 heart mass   (VT:0007028)    
Cm50 Cardiac mass QTL 50 heart mass   (VT:0007028)    
Cm51 Cardiac mass QTL 51 heart mass   (VT:0007028)    
Cm52 Cardiac mass QTL 52 heart mass   (VT:0007028)    
Cm53 Cardiac mass QTL 53 heart mass   (VT:0007028)    
Kidm29 Kidney mass QTL 29 kidney mass   (VT:0002707)    
Klgr1 Kidney lesion grade QTL 1 kidney morphology trait   (VT:0002135)    
Pur4 Proteinuria QTL 4 urine total protein amount   (VT:0000032)    
Pur5 Proteinuria QTL 5 urine total protein amount   (VT:0000032)    
Pur6 Proteinuria QTL 6 urine total protein amount   (VT:0000032)    
Uae13 Urinary albumin excretion QTL 13 urine albumin amount   (VT:0002871)    
Uae14 Urinary albumin excretion QTL 14 urine albumin amount   (VT:0002871)    
Uae15 Urinary albumin excretion QTL 15 urine albumin amount   (VT:0002871)    
Uae16 Urinary albumin excretion QTL 16 urine albumin amount   (VT:0002871)    
Uae17 Urinary albumin excretion QTL 17 urine albumin amount   (VT:0002871)    
Uae18 Urinary albumin excretion QTL 18 urine albumin amount   (VT:0002871)    
Uae19 Urinary albumin excretion QTL 19 urine albumin amount   (VT:0002871)    
Uae30 Urinary albumin excretion QTL 30 urine albumin amount   (VT:0002871)    
Uae31 Urinary albumin excretion QTL 31 urine albumin amount   (VT:0002871)    
Uae39 Urinary albumin excretion QTL 39 urine albumin amount   (VT:0002871)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
SS/Jr (ICL) 633
SS/Jr (KNAW) 701
SS/Jr (RGD) 803


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other These are genetically different from SR/Jr, according to the restriction fragment length polymorphism (RFLP) there is a mutation in every 1532 base pairs. 1358976
strain_other According to RFPLP analysis, the degree of variation between SS/Jr and Albino Surgery rats is 23% and between SS/Jr and BN rats is 71% 1358976
strain_other Mitochondrial DNA is 16,309 bp in size 2325144
strain_reproduction Produce one litter of about 8 pups, but second litter is small due to hypertension 1004
strain_reproduction Produce one litter of about 8 pups, but second litter is small due to hypertension 634612
Database Acc Id Source(s)
RRRC RRRC:00055 RGD