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Strain: SR/Jr

Symbol: SR/Jr
Strain: SR
Substrain: Jr
Full Name: Salt Resistant
RGD ID: 10040
RRID: RGD_10040
Ontology ID: RS:0000786
Also known as: RRRC:0056; SR/JrMco
Type: inbred
Source: Dr. John P. Rapp, Medical College of Ohio, USA, Rat Resource and Research Center
Origin: Originated from a Sprague-Dawley outbred colony developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for resistance to salt-induced hypertension (Dahl et al 1962a,b).
Genetic Markers: c.
Coat Color: Albino
Inbred Generations: F54.
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm





References


Region

Strain QTL Data
Symbol Name Trait
Bp167 Blood pressure QTL 167 arterial blood pressure trait   (VT:2000000)    
Bp24 Blood pressure QTL 24 arterial blood pressure trait   (VT:2000000)    
Bp25 Blood pressure QTL 25 arterial blood pressure trait   (VT:2000000)    
Bp34 Blood pressure QTL 34 arterial blood pressure trait   (VT:2000000)    
Bp39 Blood pressure QTL 39 arterial blood pressure trait   (VT:2000000)    
Bp41 Blood pressure QTL 41 blood pressure trait   (VT:0000183)    
Bp61 Blood pressure QTL 61 arterial blood pressure trait   (VT:2000000)    
Cm1 Cardiac mass QTL 1 heart mass   (VT:0007028)    
Cm13 Cardiac mass QTL 13 heart mass   (VT:0007028)    
Cm14 Cardiac mass QTL 14 heart mass   (VT:0007028)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta)(Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 61037
strain_life_disease Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta)(Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 61053
strain_other These performed significantly greater amount of work in the aerobic endurance performance as compared to the COP strain (lowest performer). 1358977
strain_other These are genetically different from SS/Jr, according to the restriction fragment length polymorphism (RFLP) there is a mutation in every 1532 base pairs. 1358976
strain_other Mitochondrial DNA is 16,309 bp in size 2325144

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-18 SR/Jr  Salt Resistant  SR/Jr  Salt Resistant  Name updated 68913 APPROVED