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Strain Registration

Strain: SR/Jr

Symbol: SR/Jr
Strain: SR
Substrain: Jr
Full Name: Salt Resistant
RGD ID: 10040
Citation ID: RRID:RRRC_00056
Ontology ID: RS:0000786
Previously known as: SR/JrMco
Type: inbred
Source: Dr. John P. Rapp, Medical College of Ohio, USA, Rat Resource and Research Center
Origin: Originated from a Sprague-Dawley outbred colony developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for resistance to salt-induced hypertension (Dahl et al 1962a,b).
Genetic Markers: c
Coat Color: Albino
Inbred Generations: F54.
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm





Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
weight loss  (IAGP)

References

References - curated
# Reference Title Reference Citation
1. Spectrum of aerobic endurance running performance in eleven inbred strains of rats. Barbato JC, etal., J Appl Physiol 1998 Aug;85(2):530-6.
2. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. Cicila GT, etal., J Hypertens 1994 Jun;12(6):643-51
3. Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats. Cicila GT, etal., Mamm Genome 1997 Dec;8(12):896-902.
4. Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats. Cicila GT, etal., Mamm Genome 1999 Feb;10(2):112-6.
5. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
6. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
7. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
8. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
9. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
10. Estimate of the genetic divergence between inbred Dahl salt-sensitive and salt-resistant rats. Ginn DI, etal., J Hypertens 1993 May;11(5):477-81.
11. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
12. Modulation of blood pressure in the Dahl SS/jr rat by embryo transfer. Kubisch HM, etal., Hypertension. 1998 Jan;31(1 Pt 2):540-5.
13. Mitochondrial polymorphisms in rat genetic models of hypertension. Kumarasamy S, etal., Mamm Genome. 2010 May 5.
14. Hereditary cataracts in the John Rapp inbred strain of Dahl salt-sensitive rat. Margo CE, etal., Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1422-8.
15. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
16. Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
17. RGD Strain RSO annotation pipeline RGD Automated Pipelines
18. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. St. Lezin EM, etal., J Clin Invest 1996 Jan 15;97(2):522-7
19. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Zhang QY, etal., Mamm Genome 1997 Sep;8(9):636-41

Region

Strain QTL Data
Symbol Name Trait
Bp167 Blood pressure QTL 167 arterial blood pressure trait   (VT:2000000)    
Bp24 Blood pressure QTL 24 arterial blood pressure trait   (VT:2000000)    
Bp25 Blood pressure QTL 25 arterial blood pressure trait   (VT:2000000)    
Bp34 Blood pressure QTL 34 arterial blood pressure trait   (VT:2000000)    
Bp39 Blood pressure QTL 39 arterial blood pressure trait   (VT:2000000)    
Bp41 Blood pressure QTL 41 blood pressure trait   (VT:0000183)    
Bp61 Blood pressure QTL 61 arterial blood pressure trait   (VT:2000000)    
Cm1 Cardiac mass QTL 1 heart mass   (VT:0007028)    
Cm13 Cardiac mass QTL 13 heart mass   (VT:0007028)    
Cm14 Cardiac mass QTL 14 heart mass   (VT:0007028)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta)(Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 61037
strain_life_disease Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta)(Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 61053
strain_other These performed significantly greater amount of work in the aerobic endurance performance as compared to the COP strain (lowest performer). 1358977
strain_other These are genetically different from SS/Jr, according to the restriction fragment length polymorphism (RFLP) there is a mutation in every 1532 base pairs. 1358976
strain_other Mitochondrial DNA is 16,309 bp in size 2325144

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-18 SR/Jr  Salt Resistant  SR/Jr  Salt Resistant  Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00056 RGD