Strain Report - Rat Genome Database
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Strain: SR/Jr

Symbol: SR/Jr
Strain: SR
Substrain: Jr
Full Name: Salt Resistant
RGD ID: 10040
RRID: RGD_10040
Ontology ID: RS:0000786
Also known as: RRRC:0056; SR/JrMco
Type: inbred
Source: Dr. John P. Rapp, Medical College of Ohio, USA, Rat Resource and Research Center
Origin: Originated from a Sprague-Dawley outbred colony developed by LK Dahl, Brookhaven National Laboratories, Upton, New York, selected for resistance to salt-induced hypertension (Dahl et al 1962a,b).
Genetic Markers: c.
Coat Color: Albino
Inbred Generations: F54.
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm





Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
weight loss  (IAGP)

References


Region

Strain QTL Data
Symbol Name Trait
Bp167 Blood pressure QTL 167 arterial blood pressure trait   (VT:2000000)    
Bp24 Blood pressure QTL 24 arterial blood pressure trait   (VT:2000000)    
Bp25 Blood pressure QTL 25 arterial blood pressure trait   (VT:2000000)    
Bp34 Blood pressure QTL 34 arterial blood pressure trait   (VT:2000000)    
Bp39 Blood pressure QTL 39 arterial blood pressure trait   (VT:2000000)    
Bp41 Blood pressure QTL 41 blood pressure trait   (VT:0000183)    
Bp61 Blood pressure QTL 61 arterial blood pressure trait   (VT:2000000)    
Cm1 Cardiac mass QTL 1 heart mass   (VT:0007028)    
Cm13 Cardiac mass QTL 13 heart mass   (VT:0007028)    
Cm14 Cardiac mass QTL 14 heart mass   (VT:0007028)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta)(Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 61037
strain_life_disease Hypertension and vascular and renal lesions do not develop on a high (8%) salt diet (cf SS, see for example, Pontremoli et al, 1992). Mild hydronephrosis at 4 months of age that is probably genetically determined (Rapp and Dene 1985). Has mutant form of cytochrome P450(11-beta)(Matsukawa et al, 1993). Has lower transepithelial, unidirectional, sodium flux than SS and Sprague-Dawley which may be associated with its resistance to the development of hypertension on a high salt diet (Kudo et al, 1994). 61053
strain_other These performed significantly greater amount of work in the aerobic endurance performance as compared to the COP strain (lowest performer). 1358977
strain_other These are genetically different from SS/Jr, according to the restriction fragment length polymorphism (RFLP) there is a mutation in every 1532 base pairs. 1358976
strain_other Mitochondrial DNA is 16,309 bp in size 2325144

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-18 SR/Jr  Salt Resistant  SR/Jr  Salt Resistant  Name updated 68913 APPROVED