Strain Report - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Strain: MR/Pit

Symbol: MR/Pit
Strain: MR
Substrain: Pit
RGD ID: 10029
RRID: RGD_10029
Ontology ID: RS:0000590
Type: inbred
Source: Not Available
Origin: As for MNR except selection was for high defecation response in the open field. To Harrington in 1965 at F25 and to NIH in 1964 at F18+ (Hansen et al 1982).
Genetic Markers: a,c,h.
Coat Color: Albino
Inbred Generations: F86(Pit).
Last Known Status: Unknown






References


Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_behavior Compared with MNR, the strain has a high open-field defecation, low ambulation, low rearing, low shock avoidance conditionability and tends to be more emotional in a wide range of behaviour (Broadhurst 1975), and have a higher preference for ethanol (Brewster 1968). Also differs from MNR in norepinephrine concentration in hypothalamus, heart, spleen and adrenal glands, suggesting that the sympathetic system might be functionally related to behavioural differences between the strains (Liang and Blizzard 1978). Lower specific benzodiazepine binding than MNR in hippocampus, hypothalamus, midbrain, medulla/pons and spinal cord, which might be a biological basis for differences in emotional behaviour (Robertson et al 1978). Long emergence latency in a novel environment in females (12/12) and also into a familiar environment in males (11/12) (Harrington 1971a). High open field defecation (1/12 males 2/12 females) (Harrington 1972). Shows substantial habituation to acoustic startle stimulous (Commissaris et al 1988). mRNA and protein populations in the brains of MR and MNR have been studied by Whatley et al (1992). 1004
strain_behavior Compared with MNR, the strain has a high open-field defecation, low ambulation, low rearing, low shock avoidance conditionability and tends to be more emotional in a wide range of behaviour (Broadhurst 1975), and have a higher preference for ethanol (Brewster 1968). Also differs from MNR in norepinephrine concentration in hypothalamus, heart, spleen and adrenal glands, suggesting that the sympathetic system might be functionally related to behavioural differences between the strains (Liang and Blizzard 1978). Lower specific benzodiazepine binding than MNR in hippocampus, hypothalamus, midbrain, medulla/pons and spinal cord, which might be a biological basis for differences in emotional behaviour (Robertson et al 1978). Long emergence latency in a novel environment in females (12/12) and also into a familiar environment in males (11/12) (Harrington 1971a). High open field defecation (1/12 males 2/12 females) (Harrington 1972). Shows substantial habituation to acoustic startle stimulous (Commissaris et al 1988). mRNA and protein populations in the brains of MR and MNR have been studied by Whatley et al (1992). 634612
strain_reproduction Good breeding performance (4/12) and large litter size (2/12) (Hansen et al 1973). See also MNR. 1004
strain_reproduction Good breeding performance (4/12) and large litter size (2/12) (Hansen et al 1973). See also MNR. 634612