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Strain Registration

Strain: MNS/Gib

Symbol: MNS/Gib
Strain: MNS
Substrain: Gib
Full Name: Milan Normotensive Strain
RGD ID: 10028
Citation ID: RRID:RGD_10028
Ontology ID: RS:0000581
Previously known as: MDC-03-67
Type: inbred
Source: Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy
Origin: Outbred Wistar rats with brother x sister mating and selection for low systolic blood pressure as a normotensive control for MHS.
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Genetic characterization of inbred strains of the rat (Rattus norvegicus). Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
2. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Calcium transport in basolateral plasma membranes from kidney cortex of Milan hypertensive rats. Gmaj P, etal., Biochim Biophys Acta. 1988 Jun 22;941(2):187-97. doi: 10.1016/0005-2736(88)90179-4.
6. Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
7. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
8. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines
10. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
11. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
12. A new rat model for studying the calpain-calpastatin system. Soldati LP, etal., Lab Anim 1995 Oct;29(4):420-6.
13. Genetic mapping of blood pressure quantitative trait loci in Milan hypertensive rats. Zagato L, etal., Hypertension 2000 Nov;36(5):734-9.

Region

Strain QTL Data
Symbol Name Trait
Bp57 Blood pressure QTL 57 arterial blood pressure trait   (VT:2000000)    
Bp58 Blood pressure QTL 58 arterial blood pressure trait   (VT:2000000)    
Bp59 Blood pressure QTL 59 arterial blood pressure trait   (VT:2000000)    
Bp60 Blood pressure QTL 60 arterial blood pressure trait   (VT:2000000)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
MNS/Gib (ICL) 646
MNS/Gib (KNAW) 810
MNS/Gib (RGD) 1131


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Have normal systolic blood pressure. 1357950
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878