Strain Report - Rat Genome Database

Name: MNS/Gib
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: MNS/Gib
Symbol:	MNS/Gib
Strain:	MNS
Substrain:	Gib
Full Name:	Milan Normotensive Strain
RGD ID:	10028
RRID:	RGD_10028
Ontology ID:	RS:0000581
Also known as:	MDC-03-67
Type:	inbred
Source:	Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy
Origin:	Outbred Wistar rats with brother x sister mating and selection for low systolic blood pressure as a normotensive control for MHS.
Last Known Status:	Unknown

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Clinical Measurement

systolic blood pressure

diastolic blood pressure

References

References - curated


1.	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
2.	Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
3.	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4.	Festing, MFW, Personal Communication Update, Feb-2000
5.	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
6.	Institute for Animal Experimentation University of Tokushima School of Medicine
7.	Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
8.	RGD Automated Pipelines
9.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
10.	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
11.	Soldati LP, etal., Lab Anim 1995 Oct;29(4):420-6.
12.	Zagato L, etal., Hypertension 2000 Nov;36(5):734-9.

Region

Strain QTL Data

Symbol	Name	Trait
Bp57	Blood pressure QTL 57	arterial blood pressure trait (VT:2000000)
Bp58	Blood pressure QTL 58	arterial blood pressure trait (VT:2000000)
Bp59	Blood pressure QTL 59	arterial blood pressure trait (VT:2000000)
Bp60	Blood pressure QTL 60	arterial blood pressure trait (VT:2000000)

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
MNS/Gib (ICL)			649
MNS/Gib (KNAW)		801
MNS/Gib (RGD)	1083

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_life_disease	Have normal systolic blood pressure.	1357950
strain_phys_biochem	This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203.	737878

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: MNS/Gib

Related Phenotype Data for Term "MNS/Gib" (RS:0000581)