Strain Report - Rat Genome Database
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Strain: M520/N

Symbol: M520/N
Strain: M520
Substrain: N
RGD ID: 10024
RRID: RGD_10024
Ontology ID: RS:0000573
Also known as: RRRC:00168
Type: inbred
Source: NIH Animal Genetic Resource, Rat Resource and Research Center
Origin: To N 1951 from Heston at F51. Developed by Curtis at Columbia University Institute for Cancer Research, 1920; to Heston, 1949 at F49.
Genetic Markers: a,c,h.
Coat Color: Albino.
Inbred Generations: F148.
Last Known Status: Cryopreserved Embryo





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Mammalian Phenotype

Phenotype Values via Phenominer     Click to see Annotation Detail View
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References


Region

Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
M520/N (KNAW) 536
M520/N (KNAW) 596
M520/N (MCW) 1322


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_immunology Low antibody response to streptococcal group A carbohydrate, which is not MHC linked (Stankus and Leslie 1976). 1004
strain_immunology Low antibody response to streptococcal group A carbohydrate, which is not MHC linked (Stankus and Leslie 1976). 634612
strain_life_disease Intermediate survival to 2 years of age at 59% in males and 62% in females. There was a relatively high incidence of mild chronic renal disease and a high incidence of hydronephrosis which may make the strain unsuitable for long-term toxicity studies (though diet may have an important influence) (Solleveld and Boorman 1986). Susceptible to Cysticercus. NIH subline has a 21-25% incidence of adrenal medulla tumours. Susceptible to induction of tumours by 2-acetylaminofluorine (Symeonidis 1954). Low frequency of pancreatic exocrine tumours. By 12-15 months of age develop small local areas of nephritis that progress by 22-24 months to moderate to severe nephritis in 75% of animals (Snell 1967). About 33% of females over 18 months develop tumours of the uterus of endometrial origin. Adrenocortical adenomas (about 20% in males and 40% in females over 18 months of age), and phaeochromocytomas or preneoplastic nodules in adrenal medulla (about 67% of males over 21 months of age) (Snell 1965). Low blood pressure (21/23), reaching 121_1.2 (SEM) mmHg at 10 weeks of age. Resistant to development of methlycholanthrene -induced thyroiditis (Glover et al 1969). 1004
strain_life_disease Intermediate survival to 2 years of age at 59% in males and 62% in females. There was a relatively high incidence of mild chronic renal disease and a high incidence of hydronephrosis which may make the strain unsuitable for long-term toxicity studies (though diet may have an important influence) (Solleveld and Boorman 1986). Susceptible to Cysticercus. NIH subline has a 21-25% incidence of adrenal medulla tumours. Susceptible to induction of tumours by 2-acetylaminofluorine (Symeonidis 1954). Low frequency of pancreatic exocrine tumours. By 12-15 months of age develop small local areas of nephritis that progress by 22-24 months to moderate to severe nephritis in 75% of animals (Snell 1967). About 33% of females over 18 months develop tumours of the uterus of endometrial origin. Adrenocortical adenomas (about 20% in males and 40% in females over 18 months of age), and phaeochromocytomas or preneoplastic nodules in adrenal medulla (about 67% of males over 21 months of age) (Snell 1965). Low blood pressure (21/23), reaching 121_1.2 (SEM) mmHg at 10 weeks of age. Resistant to development of methlycholanthrene -induced thyroiditis (Glover et al 1969). 634612
strain_phys_biochem Low systolic blood pressure (16/17) (Hansen et al 1973). Low hepatic metabolism of anilene (9/10 in males, 7/10 in females), but high metabolism of ethylmorphine (1/10) (Page and Vesell 1969). Low 10-week body weight in males (5/23) (Tanase et al 1982). High relative heart weight in 10-week old males (21/23) (Tanase et al 1982). Lacks the phenobarbital-inducible cytochrome P450 2B2 (Cyp2B2) in hepatic microsomes due to a mutation in a single autosomal gene, with codominant inheritance with respect to protein and mRNA phenotypes (see also MW) (Omiecinski et al, 1992).  
strain_phys_biochem Low systolic blood pressure (16/17) (Hansen et al 1973). Low hepatic metabolism of anilene (9/10 in males, 7/10 in females), but high metabolism of ethylmorphine (1/10) (Page and Vesell 1969). Low 10-week body weight in males (5/23) (Tanase et al 1982). High relative heart weight in 10-week old males (21/23) (Tanase et al 1982). Lacks the phenobarbital-inducible cytochrome P450 2B2 (Cyp2B2) in hepatic microsomes due to a mutation in a single autosomal gene, with codominant inheritance with respect to protein and mRNA phenotypes (see also MW) (Omiecinski et al, 1992). 1004
strain_phys_biochem Low systolic blood pressure (16/17) (Hansen et al 1973). Low hepatic metabolism of anilene (9/10 in males, 7/10 in females), but high metabolism of ethylmorphine (1/10) (Page and Vesell 1969). Low 10-week body weight in males (5/23) (Tanase et al 1982). High relative heart weight in 10-week old males (21/23) (Tanase et al 1982). Lacks the phenobarbital-inducible cytochrome P450 2B2 (Cyp2B2) in hepatic microsomes due to a mutation in a single autosomal gene, with codominant inheritance with respect to protein and mRNA phenotypes (see also MW) (Omiecinski et al, 1992). 634612
strain_reproduction Good breeding performance (2/12) and intermediate litter size (6/12) (Hansen et al 1973). 1004
strain_reproduction Good breeding performance (2/12) and intermediate litter size (6/12) (Hansen et al 1973). 634612

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-18 M520/N    M520/N    Name updated 68913 APPROVED