Strain Report - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Strain Registration

Strain: GH/Omr

Symbol: GH/Omr
Strain: GH
Substrain: Omr
Full Name: Genetically Hypertensive
RGD ID: 10016
Citation ID: RRID:RGD_10016
Ontology ID: RS:0000374
Previously known as: 619605
Type: inbred
Source: University of Otago Wellcome Med. Res. Inst, New Zealand.
Origin: This colony was established from rats of Wistar origin. This is an hysterectomy-derived colony at the University of Otago, which was established from the Wellcome Institute colony at generation 79. These have been inbred for over 90 generations.
Coat Color: Albino
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Genetically Hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. Bilusic M, etal., Croat Med J. 2008 Oct;49(5):586-99.
2. Kallikrein binding protein (KBP) maps to rat chromosome 6 but does not cosegregate with blood pressure in a GH x BN cross. Chen A, etal., Mamm Genome 1997 Sep;8(9):701-3.
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Cosegregation of the Tnfalpha locus with cardiovascular phenotypes in the F2 generation of a New Zealand genetically hypertensive and Brown Norway cross. Harris EL, etal., Clin Exp Pharmacol Physiol 1998 Mar-Apr;25(3-4):204-7.
6. Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat. Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404.
7. Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. Harris EL, etal., Physiol Genomics 2001 Aug 28;6(3):183-9.
8. PhysGen Strains PhysGen strains
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Bp322 Blood pressure QTL 322 arterial blood pressure trait   (VT:2000000)    
Bp323 Blood pressure QTL 323 arterial blood pressure trait   (VT:2000000)    
Bp324 Blood pressure QTL 324 arterial blood pressure trait   (VT:2000000)    
Bp325 Blood pressure QTL 325 arterial blood pressure trait   (VT:2000000)    
Bw81 Body weight QTL 81 body mass   (VT:0001259)    
Cm71 Cardiac mass QTL 71 heart left ventricle mass   (VT:0007031)    
Cm72 Cardiac mass QTL 72 heart left ventricle mass   (VT:0007031)    
Cm73 Cardiac mass QTL 73 heart left ventricle mass   (VT:0007031)    
Vetf1 Vascular elastic tissue fragility QTL 1 aorta elastic tissue integrity trait   (VT:0010556)    
Vetf2 Vascular elastic tissue fragility QTL 2 aorta elastic tissue integrity trait   (VT:0010556)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease They have full-blown hypertension but are not proned to internal elastic lamina lesions. 619605
strain_life_disease GH allele of Ace cosegregates with larger heart in males and females. 1357231
strain_life_disease GH allele of Ace cosegregates with increased blood pressure in females 1357231
strain_life_disease GH allele of Npr1 cosegregates with blood pressure in male rats whereas Tnf cosegregates with increased body mass in females. 1357163
strain_life_disease The development of blood pressure is not effected by salt intake. 1357231
strain_life_disease The blood pressure of females is 158 mmHg and of males is 171 mmHg. 629526
strain_other The average weight of females is 182g and of males 251g. 629526
strain_phys_biochem These have some genetic component which interacts with severity of the elastic lesion phenotype. 619605
strain_reproduction The average litter size is 8.1 pups and the average generation time is 47 days. 629526