Strain Report - Rat Genome Database

Name: BBDR/Rhw
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain: BBDR/Rhw
Symbol:	BBDR/Rhw
Strain:	BBDR
Substrain:	Rhw
RGD ID:	10003
RRID:	RGD_10003
Ontology ID:	RS:0000073
Type:	inbred
Source:	R. H. William Laboratory, University of Washington, Seattle, Washington
Origin:	S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 +/- 53 days of age after the first and 67 +/- 10 days of age after the 9th cycle.
Last Known Status:	Unknown

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Mammalian Phenotype

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References

References - curated


1.	Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2.	Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
3.	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4.	Festing, MFW, Personal Communication Update, Feb-2000
5.	Fuller JM, etal., Physiol Genomics. 2009 Apr 7.
6.	Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
7.	Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
8.	Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
9.	Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
10.	Kawahito Y, etal., Immunogenetics 1998 Oct;48(5):335-8
11.	Klaff LS, etal., Mamm Genome 1999 Sep;10(9):883-7
12.	Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
13.	Martin AM, etal., Diabetes 1999 Nov;48(11):2138-44
14.	Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
15.	RGD Automated Pipelines

Region

Strain QTL Data

Symbol	Name	Trait
Cia13	Collagen induced arthritis QTL 13	joint integrity trait (VT:0010548)
Cia15	Collagen induced arthritis QTL 15	joint integrity trait (VT:0010548)
Cia16	Collagen induced arthritis QTL 16	joint integrity trait (VT:0010548)
Cia17	Collagen induced arthritis QTL 17	joint integrity trait (VT:0010548)
Cia18	Collagen induced arthritis QTL 18	joint integrity trait (VT:0010548)
Cia19	Collagen induced arthritis QTL 19	joint integrity trait (VT:0010548)
Cia6	Collagen induced arthritis QTL 6	joint integrity trait (VT:0010548)
Cia7	Collagen induced arthritis QTL 7	joint integrity trait (VT:0010548)
Ciaa4	CIA Autoantibody QTL 4	blood autoantibody amount (VT:0003725)
Ciaa5	CIA Autoantibody QTL 5	blood autoantibody amount (VT:0003725)
Iddm2	Insulin dependent diabetes mellitus QTL 2	blood glucose amount (VT:0000188)
Iddm3	Insulin dependent diabetes mellitus QTL 3	blood glucose amount (VT:0000188)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	This strain is Diabetic Resistant.	61032
strain_reproduction	Average litter size at weaning 7.2 pups for the diabetic-resistant colonies.	61032

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2012-04-06	BBDR/Rhw	BBDR/Rhw	Name updated	68913	APPROVED
2010-09-20	BBDR/Rhw	BBDR/Rhw	Name updated	68913	APPROVED
2010-09-20	BBDR/Rhw	BBDR/Rhw	Name updated	68913	APPROVED

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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
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