Strain Report - Rat Genome Database

Name: BBDP/Rhw
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain: BBDP/Rhw
Symbol:	BBDP/Rhw
Strain:	BBDP
Substrain:	Rhw
RGD ID:	10002
RRID:	RGD_10002
Ontology ID:	RS:0000071
Type:	inbred
Source:	Not Available
Origin:	S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 ± 53 days of age after the first and 67 ± 10 days of age after the 9th cycle.
Last Known Status:	Unknown

Disease Annotations Click to see Annotation Detail View

References

References - curated


1.	Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2.	Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
3.	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4.	Festing, MFW, Personal Communication Update, Feb-2000
5.	Fuller JM, etal., Diabetes. 2006 Dec;55(12):3351-7.
6.	Fuller JM, etal., Physiol Genomics. 2009 Apr 7.
7.	Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
8.	Martin AM, etal., Diabetes 1999 Jan;48(1):50-8
9.	RGD Automated Pipelines

Region

Strain QTL Data

Symbol	Name	Trait
Iddm1	Insulin dependent diabetes mellitus QTL 1	blood glucose amount (VT:0000188)
Iddm2	Insulin dependent diabetes mellitus QTL 2	blood glucose amount (VT:0000188)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	This strain is Diabetic Prone	61032
strain_infection	These are infected by Ljungan virus (LV) which induces glucose intolerance	1601199
strain_reproduction	Average litter size at weaning 6.5 pups for diabetic-prone colonies.	61032

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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