RGD Reference Report - The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons.

Authors: Monshausen, M  Gehring, NH  Kosik, KS 
Citation: Monshausen M, etal., Neuromolecular Med. 2004;6(2-3):127-44.
RGD ID: 9999195
Pubmed: PMID:15970630   (View Abstract at PubMed)
DOI: DOI:10.1385/NMM:6:2-3:127   (Journal Full-text)

Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore protein p62, with the RNA export protein Tap and with the exon-exon junction complex (EJC) proteins Y14-Mago. The interaction of Staufen2 with the Y14-Mago heterodimer seems to represent a highly conserved complex as the same proteins are involved in the Staufen-mediated localization of oskar mRNA in Drosophila oocytes. A pool of Staufen2 is present in neuronal nuclei and colocalizes to a large degree with p62 and partly with Tap, Y14, and Mago. We suggest a model whereby a set of conserved genes in the oskar mRNA export pathway may be recruited to direct a dendritic destination for mRNAs originating as a Staufen2 nuclear complex.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rbm8aRatdendrite  IDA  RGD 
MagohbRatneuronal cell body  IDA  RGD 
Rbm8aRatneuronal cell body  IDA  RGD 
Stau2Ratnuclear membrane  IDA  RGD 

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Magohb  (mago homolog B, exon junction complex subunit)
Nup62  (nucleoporin 62)
Nxf1  (nuclear RNA export factor 1)
Rbm8a  (RNA binding motif protein 8A)
Stau2  (staufen double-stranded RNA binding protein 2)


Additional Information