RGD Reference Report - Expression of neuroglobin in ocular hypertension induced acute hypoxic-ischemic retinal injury in rats. - Rat Genome Database

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Expression of neuroglobin in ocular hypertension induced acute hypoxic-ischemic retinal injury in rats.

Authors: Shi, SY  Feng, XM  Li, Y  Li, X  Chen, XL 
Citation: Shi SY, etal., Int J Ophthalmol. 2011;4(4):393-5. doi: 10.3980/j.issn.2222-3959.2011.04.14. Epub 2011 Aug 18.
RGD ID: 9854634
Pubmed: PMID:22553688   (View Abstract at PubMed)
PMCID: PMC3340865   (View Article at PubMed Central)
DOI: DOI:10.3980/j.issn.2222-3959.2011.04.14   (Journal Full-text)

AIM: To investigate the expression of neuroglobin (Ngb) in the retina of rats with ocular hypertension induced acute retinal hypoxic-ischemic injury. METHODS: Seventy Wistar rats were divided into 7 groups randomly. The experimental model was induced by elevation of intraocular pressure via anterior chamber canula insertion in the left eyes and the fellow eyes were preserved as normal controls. The retinal tissues were taken at 1, 5, 10, 15, 20, 30 and 60 minutes after hypoxic-ischemia injury. Protein was extracted, and then analyzed by Western-blot method. SPSS was used for statistical analysis. RESULTS: The time-depended expressions of Ngb were observed. The level of Ngb increased rapidly at 1 minute after ischemia and reached to the peak at 5 minutes, which had significant difference from that of control group (P<0.05). It kept in high level during 5-15 minutes (P<0.05), then decreased after 20 minutes till 60 minutes. There were no significant differences between experimental and control group in the latter period (P>0.05). CONCLUSION: The expression of Ngb in retinal tissue increased rapidly after hypoxic-ischemic injury in rats, suggesting that Ngb may play an important role in the process of acute retinal hypoxic-ischemic injury.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NGBHumanretinal ischemia  ISONgb (Rattus norvegicus)associated with Ocular Hypertension and protein:increased expression:retinaRGD 
NgbRatretinal ischemia  IEP associated with Ocular Hypertension and protein:increased expression:retinaRGD 
NgbMouseretinal ischemia  ISONgb (Rattus norvegicus)associated with Ocular Hypertension and protein:increased expression:retinaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ngb  (neuroglobin)

Genes (Mus musculus)
Ngb  (neuroglobin)

Genes (Homo sapiens)
NGB  (neuroglobin)


Additional Information