RGD Reference Report - A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. - Rat Genome Database

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A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.

Authors: Mahajan, R  Delphin, C  Guan, T  Gerace, L  Melchior, F 
Citation: Mahajan R, etal., Cell. 1997 Jan 10;88(1):97-107.
RGD ID: 9835352
Pubmed: PMID:9019411   (View Abstract at PubMed)

We have found that the mammalian Ran GTPase-activating protein RanGAP1 is highly concentrated at the cytoplasmic periphery of the nuclear pore complex (NPC), where it associates with the 358-kDa Ran-GTP-binding protein RanBP2. This interaction requires the ATP-dependent posttranslational conjugation of RanGAP1 with SUMO-1 (for small ubiquitin-related modifier), a novel protein of 101 amino acids that contains low but significant homology to ubiquitin. SUMO-1 appears to represent the prototype for a novel family of ubiquitin-related protein modifiers. Inhibition of nuclear protein import resulting from antibodies directed at NPC-associated RanGAP1 cannot be overcome by soluble cytosolic RanGAP1, indicating that GTP hydrolysis by Ran at RanBP2 is required for nuclear protein import.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rangap1Ratcytoplasmic periphery of the nuclear pore complex  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ranbp2Ratprotein binding  IPIRangap1 (Rattus norvegicus) RGD 
Rangap1Ratprotein binding  IPIRanbp2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ranbp2  (RAN binding protein 2)
Rangap1  (RAN GTPase activating protein 1)


Additional Information