RGD Reference Report - Postage for the messenger: designating routes for nuclear mRNA export. - Rat Genome Database

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Postage for the messenger: designating routes for nuclear mRNA export.

Authors: Natalizio, BJ  Wente, SR 
Citation: Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
RGD ID: 9743967
Pubmed: PMID:23583578   (View Abstract at PubMed)
PMCID: PMC3729607   (View Article at PubMed Central)
DOI: DOI:10.1016/j.tcb.2013.03.006   (Journal Full-text)

Transcription of mRNA occurs in the nucleus, making the translocation of mRNA across the nuclear envelope (NE) boundary a critical determinant of proper gene expression and cell survival. A major mRNA export route occurs via the NXF1-dependent pathway through the nuclear pore complexes (NPCs) embedded in the NE. However, recent findings have discovered new evidence supporting the existence of multiple mechanisms for crossing the NE, including both NPC-mediated and NE budding-mediated pathways. An analysis of the trans-acting factors and cis components that define these pathways reveals shared elements as well as mechanistic differences. We review here the current understanding of the mechanisms that characterize each pathway and highlight the determinants that influence mRNA transport fate.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ANP32AHumanCRM1 export pathway  TAS  RGD 
ANP32BHumanCRM1 export pathway  TAS  RGD 
Anp32aMouseCRM1 export pathway  ISOANP32A (Homo sapiens) RGD 
Anp32aRatCRM1 export pathway  ISOANP32A (Homo sapiens) RGD 
Anp32bRatCRM1 export pathway  ISOANP32B (Homo sapiens) RGD 
Anp32bMouseCRM1 export pathway  ISOANP32B (Homo sapiens) RGD 
EIF4EHumanCRM1 export pathway  TAS  RGD 
ELAVL1HumanCRM1 export pathway  TAS  RGD 
Eif4eRatCRM1 export pathway  ISOEIF4E (Homo sapiens) RGD 
Eif4eMouseCRM1 export pathway  ISOEIF4E (Homo sapiens) RGD 
Elavl1MouseCRM1 export pathway  ISOELAVL1 (Homo sapiens) RGD 
Elavl1RatCRM1 export pathway  ISOELAVL1 (Homo sapiens) RGD 
LRPPRCHumanCRM1 export pathway  TAS  RGD 
LrpprcRatCRM1 export pathway  ISOLRPPRC (Homo sapiens) RGD 
LrpprcMouseCRM1 export pathway  ISOLRPPRC (Homo sapiens) RGD 
NUP98HumanCRM1 export pathway  TAS  RGD 
NXF3HumanCRM1 export pathway  TAS  RGD 
Nup98RatCRM1 export pathway  ISONUP98 (Homo sapiens) RGD 
Nup98MouseCRM1 export pathway  ISONUP98 (Homo sapiens) RGD 
Nxf3RatCRM1 export pathway  ISONXF3 (Homo sapiens) RGD 
Nxf3MouseCRM1 export pathway  ISONXF3 (Homo sapiens) RGD 
RANHumanCRM1 export pathway  TAS  RGD 
RANBP1HumanCRM1 export pathway  TAS  RGD 
RANBP2HumanCRM1 export pathway  TAS  RGD 
RANGAP1HumanCRM1 export pathway  TAS  RGD 
RanRatCRM1 export pathway  ISORAN (Homo sapiens) RGD 
RanMouseCRM1 export pathway  ISORAN (Homo sapiens) RGD 
Ranbp1RatCRM1 export pathway  ISORANBP1 (Homo sapiens) RGD 
Ranbp1MouseCRM1 export pathway  ISORANBP1 (Homo sapiens) RGD 
Ranbp2MouseCRM1 export pathway  ISORANBP2 (Homo sapiens) RGD 
Ranbp2RatCRM1 export pathway  ISORANBP2 (Homo sapiens) RGD 
Rangap1RatCRM1 export pathway  ISORANGAP1 (Homo sapiens) RGD 
Rangap1MouseCRM1 export pathway  ISORANGAP1 (Homo sapiens) RGD 
XPO1HumanCRM1 export pathway  TAS  RGD 
Xpo1RatCRM1 export pathway  ISOXPO1 (Homo sapiens) RGD 
Xpo1MouseCRM1 export pathway  ISOXPO1 (Homo sapiens) RGD 
DDX19BHumanNXF1-NXT1 export pathway  TAS  RGD 
Ddx19bMouseNXF1-NXT1 export pathway  ISODDX19B (Homo sapiens) RGD 
Ddx19bRatNXF1-NXT1 export pathway  ISODDX19B (Homo sapiens) RGD 
GLE1HumanNXF1-NXT1 export pathway  TAS  RGD 
Gle1RatNXF1-NXT1 export pathway  ISOGLE1 (Homo sapiens) RGD 
Gle1MouseNXF1-NXT1 export pathway  ISOGLE1 (Homo sapiens) RGD 
NUP214HumanNXF1-NXT1 export pathway  TAS  RGD 
NXF1HumanNXF1-NXT1 export pathway  TAS  RGD 
NXT1HumanNXF1-NXT1 export pathway  TAS  RGD 
Nup214RatNXF1-NXT1 export pathway  ISONUP214 (Homo sapiens) RGD 
Nup214MouseNXF1-NXT1 export pathway  ISONUP214 (Homo sapiens) RGD 
Nxf1RatNXF1-NXT1 export pathway  ISONXF1 (Homo sapiens) RGD 
Nxf1MouseNXF1-NXT1 export pathway  ISONXF1 (Homo sapiens) RGD 
Nxt1RatNXF1-NXT1 export pathway  ISONXT1 (Homo sapiens) RGD 
Nxt1MouseNXF1-NXT1 export pathway  ISONXT1 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Anp32a  (acidic nuclear phosphoprotein 32 family member A)
Anp32b  (acidic nuclear phosphoprotein 32 family member B)
Ddx19b  (DEAD-box helicase 19B)
Eif4e  (eukaryotic translation initiation factor 4E)
Elavl1  (ELAV like RNA binding protein 1)
Gle1  (GLE1 RNA export mediator)
Lrpprc  (leucine-rich pentatricopeptide repeat containing)
Nup214  (nucleoporin 214)
Nup98  (nucleoporin 98 and 96 precursor)
Nxf1  (nuclear RNA export factor 1)
Nxf3  (nuclear RNA export factor 3)
Nxt1  (nuclear transport factor 2-like export factor 1)
Ran  (RAN, member RAS oncogene family)
Ranbp1  (RAN binding protein 1)
Ranbp2  (RAN binding protein 2)
Rangap1  (RAN GTPase activating protein 1)
Xpo1  (exportin 1)

Genes (Mus musculus)
Anp32a  (acidic nuclear phosphoprotein 32 family member A)
Anp32b  (acidic nuclear phosphoprotein 32 family member B)
Ddx19b  (DEAD box helicase 19b)
Eif4e  (eukaryotic translation initiation factor 4E)
Elavl1  (ELAV like RNA binding protein 1)
Gle1  (GLE1 RNA export mediator)
Lrpprc  (leucine-rich PPR-motif containing)
Nup214  (nucleoporin 214)
Nup98  (nucleoporin 98)
Nxf1  (nuclear RNA export factor 1)
Nxf3  (nuclear RNA export factor 3)
Nxt1  (NTF2-related export protein 1)
Ran  (RAN, member RAS oncogene family)
Ranbp1  (RAN binding protein 1)
Ranbp2  (RAN binding protein 2)
Rangap1  (RAN GTPase activating protein 1)
Xpo1  (exportin 1)

Genes (Homo sapiens)
ANP32A  (acidic nuclear phosphoprotein 32 family member A)
ANP32B  (acidic nuclear phosphoprotein 32 family member B)
DDX19B  (DEAD-box helicase 19B)
EIF4E  (eukaryotic translation initiation factor 4E)
ELAVL1  (ELAV like RNA binding protein 1)
GLE1  (GLE1 RNA export mediator)
LRPPRC  (leucine rich pentatricopeptide repeat containing)
NUP214  (nucleoporin 214)
NUP98  (nucleoporin 98 and 96 precursor)
NXF1  (nuclear RNA export factor 1)
NXF3  (nuclear RNA export factor 3)
NXT1  (nuclear transport factor 2 like export factor 1)
RAN  (RAN, member RAS oncogene family)
RANBP1  (RAN binding protein 1)
RANBP2  (RAN binding protein 2)
RANGAP1  (Ran GTPase activating protein 1)
XPO1  (exportin 1)


Additional Information