RGD Reference Report - Regulation of mRNA trafficking by nuclear pore complexes. - Rat Genome Database

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Regulation of mRNA trafficking by nuclear pore complexes.

Authors: Bonnet, A  Palancade, B 
Citation: Bonnet A and Palancade B, Genes (Basel). 2014 Sep 2;5(3):767-91. doi: 10.3390/genes5030767.
RGD ID: 9743947
Pubmed: PMID:25184662   (View Abstract at PubMed)
PMCID: PMC4198930   (View Article at PubMed Central)
DOI: DOI:10.3390/genes5030767   (Journal Full-text)

Over the last two decades, multiple studies have explored the mechanisms governing mRNA export out of the nucleus, a crucial step in eukaryotic gene expression. During transcription and processing, mRNAs are assembled into messenger ribonucleoparticles (mRNPs). mRNPs are then exported through nuclear pore complexes (NPCs), which are large multiprotein assemblies made of several copies of a limited number of nucleoporins. A considerable effort has been put into the dissection of mRNA export through NPCs at both cellular and molecular levels, revealing the conserved contributions of a subset of nucleoporins in this process, from yeast to vertebrates. Several reports have also demonstrated the ability of NPCs to sort out properly-processed mRNPs for entry into the nuclear export pathway. Importantly, changes in mRNA export have been associated with post-translational modifications of nucleoporins or changes in NPC composition, depending on cell cycle progression, development or exposure to stress. How NPC modifications also impact on cellular mRNA export in disease situations, notably upon viral infection, is discussed.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NUP107HumanmRNA nuclear export pathway   TAS  RGD 
NUP133HumanmRNA nuclear export pathway   TAS  RGD 
NUP153HumanmRNA nuclear export pathway   TAS  RGD 
NUP160HumanmRNA nuclear export pathway   TAS  RGD 
NUP214HumanmRNA nuclear export pathway   TAS  RGD 
NUP37HumanmRNA nuclear export pathway   TAS  RGD 
NUP43HumanmRNA nuclear export pathway   TAS  RGD 
NUP54HumanmRNA nuclear export pathway   TAS  RGD 
NUP58HumanmRNA nuclear export pathway   TAS  RGD 
NUP62HumanmRNA nuclear export pathway   TAS  RGD 
NUP85HumanmRNA nuclear export pathway   TAS  RGD 
NUP98HumanmRNA nuclear export pathway   TAS  RGD 
Nup107RatmRNA nuclear export pathway   ISONUP107 (Homo sapiens) RGD 
Nup107MousemRNA nuclear export pathway   ISONUP107 (Homo sapiens) RGD 
Nup133RatmRNA nuclear export pathway   ISONUP133 (Homo sapiens) RGD 
Nup133MousemRNA nuclear export pathway   ISONUP133 (Homo sapiens) RGD 
Nup153RatmRNA nuclear export pathway   ISONUP153 (Homo sapiens) RGD 
Nup153MousemRNA nuclear export pathway   ISONUP153 (Homo sapiens) RGD 
Nup160RatmRNA nuclear export pathway   ISONUP160 (Homo sapiens) RGD 
Nup160MousemRNA nuclear export pathway   ISONUP160 (Homo sapiens) RGD 
Nup214RatmRNA nuclear export pathway   ISONUP214 (Homo sapiens) RGD 
Nup214MousemRNA nuclear export pathway   ISONUP214 (Homo sapiens) RGD 
Nup37RatmRNA nuclear export pathway   ISONUP37 (Homo sapiens) RGD 
Nup37MousemRNA nuclear export pathway   ISONUP37 (Homo sapiens) RGD 
Nup43RatmRNA nuclear export pathway   ISONUP43 (Homo sapiens) RGD 
Nup43MousemRNA nuclear export pathway   ISONUP43 (Homo sapiens) RGD 
Nup54RatmRNA nuclear export pathway   ISONUP54 (Homo sapiens) RGD 
Nup54MousemRNA nuclear export pathway   ISONUP54 (Homo sapiens) RGD 
Nup58RatmRNA nuclear export pathway   ISONUP58 (Homo sapiens) RGD 
Nup58MousemRNA nuclear export pathway   ISONUP58 (Homo sapiens) RGD 
Nup62RatmRNA nuclear export pathway   ISONUP62 (Homo sapiens) RGD 
Nup62MousemRNA nuclear export pathway   ISONUP62 (Homo sapiens) RGD 
Nup85RatmRNA nuclear export pathway   ISONUP85 (Homo sapiens) RGD 
Nup85MousemRNA nuclear export pathway   ISONUP85 (Homo sapiens) RGD 
Nup98RatmRNA nuclear export pathway   ISONUP98 (Homo sapiens) RGD 
Nup98MousemRNA nuclear export pathway   ISONUP98 (Homo sapiens) RGD 
SEC13HumanmRNA nuclear export pathway   TAS  RGD 
SEH1LHumanmRNA nuclear export pathway   TAS  RGD 
Sec13RatmRNA nuclear export pathway   ISOSEC13 (Homo sapiens) RGD 
Sec13MousemRNA nuclear export pathway   ISOSEC13 (Homo sapiens) RGD 
Seh1lMousemRNA nuclear export pathway   ISOSEH1L (Homo sapiens) RGD 
Seh1lRatmRNA nuclear export pathway   ISOSEH1L (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Nup107  (nucleoporin 107)
Nup133  (nucleoporin 133)
Nup153  (nucleoporin 153)
Nup160  (nucleoporin 160)
Nup214  (nucleoporin 214)
Nup37  (nucleoporin 37)
Nup43  (nucleoporin 43)
Nup54  (nucleoporin 54)
Nup58  (nucleoporin 58)
Nup62  (nucleoporin 62)
Nup85  (nucleoporin 85)
Nup98  (nucleoporin 98 and 96 precursor)
Sec13  (SEC13 homolog, nuclear pore and COPII coat complex component)
Seh1l  (SEH1-like nucleoporin)

Genes (Mus musculus)
Nup107  (nucleoporin 107)
Nup133  (nucleoporin 133)
Nup153  (nucleoporin 153)
Nup160  (nucleoporin 160)
Nup214  (nucleoporin 214)
Nup37  (nucleoporin 37)
Nup43  (nucleoporin 43)
Nup54  (nucleoporin 54)
Nup58  (nucleoporin 58)
Nup62  (nucleoporin 62)
Nup85  (nucleoporin 85)
Nup98  (nucleoporin 98)
Sec13  (SEC13 homolog, nuclear pore and COPII coat complex component)
Seh1l  (SEH1-like (S. cerevisiae)

Genes (Homo sapiens)
NUP107  (nucleoporin 107)
NUP133  (nucleoporin 133)
NUP153  (nucleoporin 153)
NUP160  (nucleoporin 160)
NUP214  (nucleoporin 214)
NUP37  (nucleoporin 37)
NUP43  (nucleoporin 43)
NUP54  (nucleoporin 54)
NUP58  (nucleoporin 58)
NUP62  (nucleoporin 62)
NUP85  (nucleoporin 85)
NUP98  (nucleoporin 98 and 96 precursor)
SEC13  (SEC13 homolog, nuclear pore and COPII coat complex component)
SEH1L  (SEH1 like nucleoporin)


Additional Information