RGD Reference Report - GREB1 tissue expression is associated with organ-confined prostate cancer. - Rat Genome Database

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GREB1 tissue expression is associated with organ-confined prostate cancer.

Authors: Antunes, AA  Leite, KR  Reis, ST  Sousa-Canavez, JM  Camara-Lopes, LH  Dall'oglio, MF  Srougi, M 
Citation: Antunes AA, etal., Urol Oncol. 2012 Jan-Feb;30(1):16-20. doi: 10.1016/j.urolonc.2009.09.014. Epub 2009 Nov 27.
RGD ID: 9693724
Pubmed: PMID:19945309   (View Abstract at PubMed)
DOI: DOI:10.1016/j.urolonc.2009.09.014   (Journal Full-text)

OBJECTIVE: By reason of its heterogeneous behavior, it is difficult to determine the prognosis of many prostate cancer cases. Patients with the same clinicopathologic conditions may present varying clinical findings and rates of progression. We determined the role of new genes as potential molecular markers for prostate cancer prognosis. MATERIALS AND METHODS: We performed a microarray analysis of two pools of patients with prostate cancer divided according to their clinicopathologic characteristics. After that, we validated these results by testing the genes with most different expressions between the two pools using the quantitative real time polymerase chain reaction method. We analyzed gene expression in 33 patients with localized prostate cancer according to prostate specific antigen (PSA), pathologic stage, Gleason score, and biochemical recurrence. For statistical analysis we used the Mann-Whitney Test. RESULTS: The microarray analysis revealed that 4,147 genes presented a different expression between the two pools. Among them, 3 genes, TMEFF2, GREB1, and TH1L, were at least 13-times overexpressed, and 1 gene, IGH3, which was at least 5 times under-expressed in pool 1 (good prognosis) compared with pool 2 (bad prognosis), were selected for analysis. After the validation tests, GREB1 was significantly more overexpressed among patients with stage T2 compared with T3 (P = 0.020). The expressions of other 3 genes did not present significant differences according to the clinicopathological variables. CONCLUSIONS: Tissue expression of GREB1 is associated with organ-confined prostate cancer and may constitute a gene associated with a favorable prognosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NELFCDHumanprostate cancer disease_progressionIEP  RGD 
NelfcdRatprostate cancer disease_progressionISONELFCD (Homo sapiens) RGD 
NelfcdMouseprostate cancer disease_progressionISONELFCD (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nelfcd  (negative elongation factor complex member C/D)

Genes (Mus musculus)
Nelfcd  (negative elongation factor complex member C/D, Th1l)

Genes (Homo sapiens)
NELFCD  (negative elongation factor complex member C/D)


Additional Information