RGD Reference Report - Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. - Rat Genome Database

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Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.

Authors: Chen, YI  Moore, RE  Ge, HY  Young, MK  Lee, TD  Stevens, SW 
Citation: Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
RGD ID: 9686091
Pubmed: PMID:17537823   (View Abstract at PubMed)
PMCID: PMC1919476   (View Article at PubMed Central)
DOI: DOI:10.1093/nar/gkm347   (Journal Full-text)

Previous compositional studies of pre-mRNA processing complexes have been performed in vitro on synthetic pre-mRNAs containing a single intron. To provide a more comprehensive list of polypeptides associated with the pre-mRNA splicing apparatus, we have determined the composition of the bulk pre-mRNA processing machinery in living cells. We purified endogenous nuclear pre-mRNA processing complexes from human and chicken cells comprising the massive (>200S) supraspliceosomes (a.k.a. polyspliceosomes). As expected, RNA components include a heterogeneous mixture of pre-mRNAs and the five spliceosomal snRNAs. In addition to known pre-mRNA splicing factors, 5' end binding factors, 3' end processing factors, mRNA export factors, hnRNPs and other RNA binding proteins, the protein components identified by mass spectrometry include RNA adenosine deaminases and several novel factors. Intriguingly, our purified supraspliceosomes also contain a number of structural proteins, nucleoporins, chromatin remodeling factors and several novel proteins that were absent from splicing complexes assembled in vitro. These in vivo analyses bring the total number of factors associated with pre-mRNA to well over 300, and represent the most comprehensive analysis of the pre-mRNA processing machinery to date.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DDX42Humanspliceosome pathway   TAS  RGD 
Ddx42Ratspliceosome pathway   ISODDX42 (Homo sapiens) RGD 
Ddx42Mousespliceosome pathway   ISODDX42 (Homo sapiens) RGD 
HNRNPA0Humanspliceosome pathway   TAS  RGD 
HNRNPA1Humanspliceosome pathway   TAS  RGD 
HNRNPA2B1Humanspliceosome pathway   TAS  RGD 
HNRNPA3Humanspliceosome pathway   TAS  RGD 
HNRNPABHumanspliceosome pathway   TAS  RGD 
HNRNPCHumanspliceosome pathway   TAS  RGD 
HNRNPDHumanspliceosome pathway   TAS  RGD 
HNRNPH1Humanspliceosome pathway   TAS  RGD 
HNRNPH3Humanspliceosome pathway   TAS  RGD 
HNRNPKHumanspliceosome pathway   TAS  RGD 
HNRNPLHumanspliceosome pathway   TAS  RGD 
HNRNPMHumanspliceosome pathway   TAS  RGD 
HNRNPRHumanspliceosome pathway   TAS  RGD 
HNRNPUHumanspliceosome pathway   TAS  RGD 
Hnrnpa0Mousespliceosome pathway   ISOHNRNPA0 (Homo sapiens) RGD 
Hnrnpa0Ratspliceosome pathway   ISOHNRNPA0 (Homo sapiens) RGD 
Hnrnpa1Ratspliceosome pathway   ISOHNRNPA1 (Homo sapiens) RGD 
Hnrnpa1Mousespliceosome pathway   ISOHNRNPA1 (Homo sapiens) RGD 
Hnrnpa2b1Ratspliceosome pathway   ISOHNRNPA2B1 (Homo sapiens) RGD 
Hnrnpa2b1Mousespliceosome pathway   ISOHNRNPA2B1 (Homo sapiens) RGD 
Hnrnpa3Mousespliceosome pathway   ISOHNRNPA3 (Homo sapiens) RGD 
HnrnpabRatspliceosome pathway   ISOHNRNPAB (Homo sapiens) RGD 
HnrnpabMousespliceosome pathway   ISOHNRNPAB (Homo sapiens) RGD 
HnrnpcRatspliceosome pathway   ISOHNRNPC (Homo sapiens) RGD 
HnrnpcMousespliceosome pathway   ISOHNRNPC (Homo sapiens) RGD 
HnrnpdRatspliceosome pathway   ISOHNRNPD (Homo sapiens) RGD 
HnrnpdMousespliceosome pathway   ISOHNRNPD (Homo sapiens) RGD 
Hnrnph1Ratspliceosome pathway   ISOHNRNPH1 (Homo sapiens) RGD 
Hnrnph1Mousespliceosome pathway   ISOHNRNPH1 (Homo sapiens) RGD 
Hnrnph3Mousespliceosome pathway   ISOHNRNPH3 (Homo sapiens) RGD 
HnrnpkRatspliceosome pathway   ISOHNRNPK (Homo sapiens) RGD 
HnrnpkMousespliceosome pathway   ISOHNRNPK (Homo sapiens) RGD 
HnrnplRatspliceosome pathway   ISOHNRNPL (Homo sapiens) RGD 
HnrnplMousespliceosome pathway   ISOHNRNPL (Homo sapiens) RGD 
HnrnpmRatspliceosome pathway   ISOHNRNPM (Homo sapiens) RGD 
HnrnpmMousespliceosome pathway   ISOHNRNPM (Homo sapiens) RGD 
HnrnprRatspliceosome pathway   ISOHNRNPR (Homo sapiens) RGD 
HnrnprMousespliceosome pathway   ISOHNRNPR (Homo sapiens) RGD 
HnrnpuRatspliceosome pathway   ISOHNRNPU (Homo sapiens) RGD 
HnrnpuMousespliceosome pathway   ISOHNRNPU (Homo sapiens) RGD 
LSM2Humanspliceosome pathway   TAS  RGD 
LSM3Humanspliceosome pathway   TAS  RGD 
LSM4Humanspliceosome pathway   TAS  RGD 
LSM5Humanspliceosome pathway   TAS  RGD 
LSM6Humanspliceosome pathway   TAS  RGD 
LSM7Humanspliceosome pathway   TAS  RGD 
LSM8Humanspliceosome pathway   TAS  RGD 
Lsm2Ratspliceosome pathway   ISOLSM2 (Homo sapiens) RGD 
Lsm2Mousespliceosome pathway   ISOLSM2 (Homo sapiens) RGD 
Lsm3Ratspliceosome pathway   ISOLSM3 (Homo sapiens) RGD 
Lsm3Mousespliceosome pathway   ISOLSM3 (Homo sapiens) RGD 
Lsm4Ratspliceosome pathway   ISOLSM4 (Homo sapiens) RGD 
Lsm4Mousespliceosome pathway   ISOLSM4 (Homo sapiens) RGD 
Lsm5Mousespliceosome pathway   ISOLSM5 (Homo sapiens) RGD 
Lsm6Mousespliceosome pathway   ISOLSM6 (Homo sapiens) RGD 
Lsm6Ratspliceosome pathway   ISOLSM6 (Homo sapiens) RGD 
Lsm7Ratspliceosome pathway   ISOLSM7 (Homo sapiens) RGD 
Lsm8Ratspliceosome pathway   ISOLSM8 (Homo sapiens) RGD 
Lsm8Mousespliceosome pathway   ISOLSM8 (Homo sapiens) RGD 
RBMXHumanspliceosome pathway   TAS  RGD 
RbmxMousespliceosome pathway   ISORBMX (Homo sapiens) RGD 
RbmxRatspliceosome pathway   ISORBMX (Homo sapiens) RGD 
SF3A1Humanspliceosome pathway   TAS  RGD 
SF3A2Humanspliceosome pathway   TAS  RGD 
SF3A3Humanspliceosome pathway   TAS  RGD 
SF3B1Humanspliceosome pathway   TAS  RGD 
SF3B2Humanspliceosome pathway   TAS  RGD 
SF3B3Humanspliceosome pathway   TAS  RGD 
SF3B4Humanspliceosome pathway   TAS  RGD 
SF3B5Humanspliceosome pathway   TAS  RGD 
SF3B6Humanspliceosome pathway   TAS  RGD 
SNRPA1Humanspliceosome pathway   TAS  RGD 
SNRPBHumanspliceosome pathway   TAS  RGD 
SNRPB2Humanspliceosome pathway   TAS  RGD 
SNRPD1Humanspliceosome pathway   TAS  RGD 
SNRPD2Humanspliceosome pathway   TAS  RGD 
SNRPD3Humanspliceosome pathway   TAS  RGD 
SNRPEHumanspliceosome pathway   TAS  RGD 
SNRPFHumanspliceosome pathway   TAS  RGD 
SNRPGHumanspliceosome pathway   TAS  RGD 
SRRM1Humanspliceosome pathway   TAS  RGD 
SRRM2Humanspliceosome pathway   TAS  RGD 
SRSF1Humanspliceosome pathway   TAS  RGD 
SRSF10Humanspliceosome pathway   TAS  RGD 
SRSF11Humanspliceosome pathway   TAS  RGD 
SRSF12Humanspliceosome pathway   TAS  RGD 
SRSF2Humanspliceosome pathway   TAS  RGD 
SRSF3Humanspliceosome pathway   TAS  RGD 
SRSF4Humanspliceosome pathway   TAS  RGD 
SRSF5Humanspliceosome pathway   TAS  RGD 
SRSF6Humanspliceosome pathway   TAS  RGD 
SRSF7Humanspliceosome pathway   TAS  RGD 
SRSF9Humanspliceosome pathway   TAS  RGD 
SYNCRIPHumanspliceosome pathway   TAS  RGD 
Sf3a1Ratspliceosome pathway   ISOSF3A1 (Homo sapiens) RGD 
Sf3a1Mousespliceosome pathway   ISOSF3A1 (Homo sapiens) RGD 
Sf3a2Ratspliceosome pathway   ISOSF3A2 (Homo sapiens) RGD 
Sf3a2Mousespliceosome pathway   ISOSF3A2 (Homo sapiens) RGD 
Sf3a3Ratspliceosome pathway   ISOSF3A3 (Homo sapiens) RGD 
Sf3a3Mousespliceosome pathway   ISOSF3A3 (Homo sapiens) RGD 
Sf3b1Ratspliceosome pathway   ISOSF3B1 (Homo sapiens) RGD 
Sf3b1Mousespliceosome pathway   ISOSF3B1 (Homo sapiens) RGD 
Sf3b2Ratspliceosome pathway   ISOSF3B2 (Homo sapiens) RGD 
Sf3b2Mousespliceosome pathway   ISOSF3B2 (Homo sapiens) RGD 
Sf3b3Ratspliceosome pathway   ISOSF3B3 (Homo sapiens) RGD 
Sf3b3Mousespliceosome pathway   ISOSF3B3 (Homo sapiens) RGD 
Sf3b4Ratspliceosome pathway   ISOSF3B4 (Homo sapiens) RGD 
Sf3b4Mousespliceosome pathway   ISOSF3B4 (Homo sapiens) RGD 
Sf3b5Ratspliceosome pathway   ISOSF3B5 (Homo sapiens) RGD 
Sf3b5Mousespliceosome pathway   ISOSF3B5 (Homo sapiens) RGD 
Sf3b6Mousespliceosome pathway   ISOSF3B6 (Homo sapiens) RGD 
Sf3b6Ratspliceosome pathway   ISOSF3B6 (Homo sapiens) RGD 
Snrpa1Mousespliceosome pathway   ISOSNRPA1 (Homo sapiens) RGD 
Snrpa1Ratspliceosome pathway   ISOSNRPA1 (Homo sapiens) RGD 
SnrpbRatspliceosome pathway   ISOSNRPB (Homo sapiens) RGD 
SnrpbMousespliceosome pathway   ISOSNRPB (Homo sapiens) RGD 
Snrpb2Ratspliceosome pathway   ISOSNRPB2 (Homo sapiens) RGD 
Snrpb2Mousespliceosome pathway   ISOSNRPB2 (Homo sapiens) RGD 
Snrpd1Ratspliceosome pathway   ISOSNRPD1 (Homo sapiens) RGD 
Snrpd1Mousespliceosome pathway   ISOSNRPD1 (Homo sapiens) RGD 
Snrpd2Mousespliceosome pathway   ISOSNRPD2 (Homo sapiens) RGD 
Snrpd2Ratspliceosome pathway   ISOSNRPD2 (Homo sapiens) RGD 
Snrpd3Ratspliceosome pathway   ISOSNRPD3 (Homo sapiens) RGD 
Snrpd3Mousespliceosome pathway   ISOSNRPD3 (Homo sapiens) RGD 
SnrpeMousespliceosome pathway   ISOSNRPE (Homo sapiens) RGD 
SnrpeRatspliceosome pathway   ISOSNRPE (Homo sapiens) RGD 
SnrpfRatspliceosome pathway   ISOSNRPF (Homo sapiens) RGD 
SnrpfMousespliceosome pathway   ISOSNRPF (Homo sapiens) RGD 
SnrpgRatspliceosome pathway   ISOSNRPG (Homo sapiens) RGD 
SnrpgMousespliceosome pathway   ISOSNRPG (Homo sapiens) RGD 
Srrm1Ratspliceosome pathway   ISOSRRM1 (Homo sapiens) RGD 
Srrm1Mousespliceosome pathway   ISOSRRM1 (Homo sapiens) RGD 
Srrm2Ratspliceosome pathway   ISOSRRM2 (Homo sapiens) RGD 
Srrm2Mousespliceosome pathway   ISOSRRM2 (Homo sapiens) RGD 
Srsf1Ratspliceosome pathway   ISOSRSF1 (Homo sapiens) RGD 
Srsf1Mousespliceosome pathway   ISOSRSF1 (Homo sapiens) RGD 
Srsf10Ratspliceosome pathway   ISOSRSF10 (Homo sapiens) RGD 
Srsf10Mousespliceosome pathway   ISOSRSF10 (Homo sapiens) RGD 
Srsf11Mousespliceosome pathway   ISOSRSF11 (Homo sapiens) RGD 
Srsf11Ratspliceosome pathway   ISOSRSF11 (Homo sapiens) RGD 
Srsf12Ratspliceosome pathway   ISOSRSF12 (Homo sapiens) RGD 
Srsf12Mousespliceosome pathway   ISOSRSF12 (Homo sapiens) RGD 
Srsf2Ratspliceosome pathway   ISOSRSF2 (Homo sapiens) RGD 
Srsf2Mousespliceosome pathway   ISOSRSF2 (Homo sapiens) RGD 
Srsf3Mousespliceosome pathway   ISOSRSF3 (Homo sapiens) RGD 
Srsf4Ratspliceosome pathway   ISOSRSF4 (Homo sapiens) RGD 
Srsf4Mousespliceosome pathway   ISOSRSF4 (Homo sapiens) RGD 
Srsf5Ratspliceosome pathway   ISOSRSF5 (Homo sapiens) RGD 
Srsf5Mousespliceosome pathway   ISOSRSF5 (Homo sapiens) RGD 
Srsf6Ratspliceosome pathway   ISOSRSF6 (Homo sapiens) RGD 
Srsf6Mousespliceosome pathway   ISOSRSF6 (Homo sapiens) RGD 
Srsf7Ratspliceosome pathway   ISOSRSF7 (Homo sapiens) RGD 
Srsf7Mousespliceosome pathway   ISOSRSF7 (Homo sapiens) RGD 
Srsf9Ratspliceosome pathway   ISOSRSF9 (Homo sapiens) RGD 
Srsf9Mousespliceosome pathway   ISOSRSF9 (Homo sapiens) RGD 
SyncripRatspliceosome pathway   ISOSYNCRIP (Homo sapiens) RGD 
SyncripMousespliceosome pathway   ISOSYNCRIP (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ddx42  (DEAD-box helicase 42)
Hnrnpa0  (heterogeneous nuclear ribonucleoprotein A0)
Hnrnpa1  (heterogeneous nuclear ribonucleoprotein A1)
Hnrnpa2b1  (heterogeneous nuclear ribonucleoprotein A2/B1)
Hnrnpab  (heterogeneous nuclear ribonucleoprotein A/B)
Hnrnpc  (heterogeneous nuclear ribonucleoprotein C)
Hnrnpd  (heterogeneous nuclear ribonucleoprotein D)
Hnrnph1  (heterogeneous nuclear ribonucleoprotein H1)
Hnrnpk  (heterogeneous nuclear ribonucleoprotein K)
Hnrnpl  (heterogeneous nuclear ribonucleoprotein L)
Hnrnpm  (heterogeneous nuclear ribonucleoprotein M)
Hnrnpr  (heterogeneous nuclear ribonucleoprotein R)
Hnrnpu  (heterogeneous nuclear ribonucleoprotein U)
Lsm2  (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm3  (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm4  (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm6  (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm7  (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm8  (LSM8 homolog, U6 small nuclear RNA associated)
Rbmx  (RNA binding motif protein, X-linked)
Sf3a1  (splicing factor 3A subunit 1)
Sf3a2  (splicing factor 3A subunit 2)
Sf3a3  (splicing factor 3a, subunit 3)
Sf3b1  (splicing factor 3b, subunit 1)
Sf3b2  (splicing factor 3b, subunit 2)
Sf3b3  (splicing factor 3b, subunit 3)
Sf3b4  (splicing factor 3B subunit 4)
Sf3b5  (splicing factor 3b, subunit 5)
Sf3b6  (splicing factor 3B, subunit 6)
Snrpa1  (small nuclear ribonucleoprotein polypeptide A')
Snrpb  (small nuclear ribonucleoprotein polypeptides B and B1)
Snrpb2  (small nuclear ribonucleoprotein polypeptide B2)
Snrpd1  (small nuclear ribonucleoprotein D1 polypeptide)
Snrpd2  (small nuclear ribonucleoprotein D2 polypeptide)
Snrpd3  (small nuclear ribonucleoprotein D3 polypeptide)
Snrpe  (small nuclear ribonucleoprotein polypeptide E)
Snrpf  (small nuclear ribonucleoprotein polypeptide F)
Snrpg  (small nuclear ribonucleoprotein polypeptide G)
Srrm1  (serine and arginine repetitive matrix 1)
Srrm2  (serine/arginine repetitive matrix 2)
Srsf1  (serine and arginine rich splicing factor 1)
Srsf10  (serine and arginine rich splicing factor 10)
Srsf11  (serine and arginine rich splicing factor 11)
Srsf12  (serine and arginine rich splicing factor 12)
Srsf2  (serine and arginine rich splicing factor 2)
Srsf4  (serine and arginine rich splicing factor 4)
Srsf5  (serine and arginine rich splicing factor 5)
Srsf6  (serine and arginine rich splicing factor 6)
Srsf7  (serine and arginine rich splicing factor 7)
Srsf9  (serine and arginine rich splicing factor 9)
Syncrip  (synaptotagmin binding, cytoplasmic RNA interacting protein)

Genes (Mus musculus)
Ddx42  (DEAD box helicase 42)
Hnrnpa0  (heterogeneous nuclear ribonucleoprotein A0)
Hnrnpa1  (heterogeneous nuclear ribonucleoprotein A1)
Hnrnpa2b1  (heterogeneous nuclear ribonucleoprotein A2/B1)
Hnrnpa3  (heterogeneous nuclear ribonucleoprotein A3)
Hnrnpab  (heterogeneous nuclear ribonucleoprotein A/B)
Hnrnpc  (heterogeneous nuclear ribonucleoprotein C)
Hnrnpd  (heterogeneous nuclear ribonucleoprotein D)
Hnrnph1  (heterogeneous nuclear ribonucleoprotein H1)
Hnrnph3  (heterogeneous nuclear ribonucleoprotein H3)
Hnrnpk  (heterogeneous nuclear ribonucleoprotein K)
Hnrnpl  (heterogeneous nuclear ribonucleoprotein L)
Hnrnpm  (heterogeneous nuclear ribonucleoprotein M)
Hnrnpr  (heterogeneous nuclear ribonucleoprotein R)
Hnrnpu  (heterogeneous nuclear ribonucleoprotein U)
Lsm2  (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm3  (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm4  (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm5  (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm6  (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm8  (LSM8 homolog, U6 small nuclear RNA associated)
Rbmx  (RNA binding motif protein, X chromosome)
Sf3a1  (splicing factor 3a, subunit 1)
Sf3a2  (splicing factor 3a, subunit 2)
Sf3a3  (splicing factor 3a, subunit 3)
Sf3b1  (splicing factor 3b, subunit 1)
Sf3b2  (splicing factor 3b, subunit 2)
Sf3b3  (splicing factor 3b, subunit 3)
Sf3b4  (splicing factor 3b, subunit 4)
Sf3b5  (splicing factor 3b, subunit 5)
Sf3b6  (splicing factor 3B, subunit 6)
Snrpa1  (small nuclear ribonucleoprotein polypeptide A')
Snrpb  (small nuclear ribonucleoprotein B)
Snrpb2  (U2 small nuclear ribonucleoprotein B)
Snrpd1  (small nuclear ribonucleoprotein D1)
Snrpd2  (small nuclear ribonucleoprotein D2)
Snrpd3  (small nuclear ribonucleoprotein D3)
Snrpe  (small nuclear ribonucleoprotein E)
Snrpf  (small nuclear ribonucleoprotein polypeptide F)
Snrpg  (small nuclear ribonucleoprotein polypeptide G)
Srrm1  (serine/arginine repetitive matrix 1)
Srrm2  (serine/arginine repetitive matrix 2)
Srsf1  (serine and arginine-rich splicing factor 1)
Srsf10  (serine and arginine-rich splicing factor 10)
Srsf11  (serine and arginine-rich splicing factor 11)
Srsf12  (serine and arginine-rich splicing factor 12)
Srsf2  (serine and arginine-rich splicing factor 2)
Srsf3  (serine and arginine-rich splicing factor 3)
Srsf4  (serine and arginine-rich splicing factor 4)
Srsf5  (serine and arginine-rich splicing factor 5)
Srsf6  (serine and arginine-rich splicing factor 6)
Srsf7  (serine and arginine-rich splicing factor 7)
Srsf9  (serine and arginine-rich splicing factor 9)
Syncrip  (synaptotagmin binding, cytoplasmic RNA interacting protein)

Genes (Homo sapiens)
DDX42  (DEAD-box helicase 42)
HNRNPA0  (heterogeneous nuclear ribonucleoprotein A0)
HNRNPA1  (heterogeneous nuclear ribonucleoprotein A1)
HNRNPA2B1  (heterogeneous nuclear ribonucleoprotein A2/B1)
HNRNPA3  (heterogeneous nuclear ribonucleoprotein A3)
HNRNPAB  (heterogeneous nuclear ribonucleoprotein A/B)
HNRNPC  (heterogeneous nuclear ribonucleoprotein C)
HNRNPD  (heterogeneous nuclear ribonucleoprotein D)
HNRNPH1  (heterogeneous nuclear ribonucleoprotein H1)
HNRNPH3  (heterogeneous nuclear ribonucleoprotein H3)
HNRNPK  (heterogeneous nuclear ribonucleoprotein K)
HNRNPL  (heterogeneous nuclear ribonucleoprotein L)
HNRNPM  (heterogeneous nuclear ribonucleoprotein M)
HNRNPR  (heterogeneous nuclear ribonucleoprotein R)
HNRNPU  (heterogeneous nuclear ribonucleoprotein U)
LSM2  (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM3  (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM4  (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM5  (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM6  (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM7  (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM8  (LSM8 homolog, U6 small nuclear RNA associated)
RBMX  (RNA binding motif protein X-linked)
SF3A1  (splicing factor 3a subunit 1)
SF3A2  (splicing factor 3a subunit 2)
SF3A3  (splicing factor 3a subunit 3)
SF3B1  (splicing factor 3b subunit 1)
SF3B2  (splicing factor 3b subunit 2)
SF3B3  (splicing factor 3b subunit 3)
SF3B4  (splicing factor 3b subunit 4)
SF3B5  (splicing factor 3b subunit 5)
SF3B6  (splicing factor 3b subunit 6)
SNRPA1  (small nuclear ribonucleoprotein polypeptide A')
SNRPB  (small nuclear ribonucleoprotein polypeptides B and B1)
SNRPB2  (small nuclear ribonucleoprotein polypeptide B2)
SNRPD1  (small nuclear ribonucleoprotein D1 polypeptide)
SNRPD2  (small nuclear ribonucleoprotein D2 polypeptide)
SNRPD3  (small nuclear ribonucleoprotein D3 polypeptide)
SNRPE  (small nuclear ribonucleoprotein polypeptide E)
SNRPF  (small nuclear ribonucleoprotein polypeptide F)
SNRPG  (small nuclear ribonucleoprotein polypeptide G)
SRRM1  (serine and arginine repetitive matrix 1)
SRRM2  (serine/arginine repetitive matrix 2)
SRSF1  (serine and arginine rich splicing factor 1)
SRSF10  (serine and arginine rich splicing factor 10)
SRSF11  (serine and arginine rich splicing factor 11)
SRSF12  (serine and arginine rich splicing factor 12)
SRSF2  (serine and arginine rich splicing factor 2)
SRSF3  (serine and arginine rich splicing factor 3)
SRSF4  (serine and arginine rich splicing factor 4)
SRSF5  (serine and arginine rich splicing factor 5)
SRSF6  (serine and arginine rich splicing factor 6)
SRSF7  (serine and arginine rich splicing factor 7)
SRSF9  (serine and arginine rich splicing factor 9)
SYNCRIP  (synaptotagmin binding cytoplasmic RNA interacting protein)


Additional Information