RGD Reference Report - Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase. - Rat Genome Database

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Thalamocortical projections have a K+ channel that is phosphorylated and modulated by cAMP-dependent protein kinase.

Authors: Moreno, H  Kentros, C  Bueno, E  Weiser, M  Hernandez, A  Vega-Saenz de Miera, E  Ponce, A  Thornhill, W  Rudy, B 
Citation: Moreno H, etal., J Neurosci. 1995 Aug;15(8):5486-501.
RGD ID: 9686052
Pubmed: PMID:7643197   (View Abstract at PubMed)
PMCID: PMC6577618   (View Article at PubMed Central)

The finding that some K+ channel mRNAs are restricted to certain populations of neurons in the CNS suggests that there are K+ channels tailored to certain neuronal circuits. One such example are the transcripts from the KV3.2 gene, the majority of which are expressed in thalamic relay neurons. To gain insights into the specific roles of KV3.2 subunits, site specific antibodies were raised to determine their localization in thalamic relay neurons. Immunohistochemical and focal lesioning studies demonstrate that KV3.2 proteins are localized to the terminal fields of thalamocortical projections. It is also shown that KV3.2 channels expressed in vitro are strongly inhibited through phosphorylation by cAMP-dependent protein kinase (PKA). Channels containing KV3.1 subunits, which otherwise exhibit nearly identical electrophysiological properties in heterologous expression systems but have a different and less restricted pattern of expression in the CNS, are not affected by PKA. Therefore, this modulation might be associated with the specific roles of KV3.2 subunits. Furthermore, we demonstrate that KV3.2 proteins can be phosphorylated in situ by intrinsic PKA. KV3.2 subunits display properties and have a localization consistent with a role in the regulation of the efficacy of the thalamocortical synapse, and could thereby participate in the neurotransmitter-mediated control of functional states of the thalamocortical system associated with global states of awareness.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnc2Ratpotassium ion transmembrane transport involved_inIDA PMID:7643197UniProt 
Kcnc2Ratresponse to kainic acid  IEP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnc2Rataxon located_inIDA PMID:7643197UniProt 
Kcnc2Ratintracellular membrane-bounded organelle  IDA  RGD 
Kcnc2Ratmembrane  IDA  RGD 
Kcnc2Ratneuronal cell body membrane located_inIDA PMID:7643197UniProt 
Kcnc2Ratsynapse located_inIDA PMID:7643197UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnc2Ratdelayed rectifier potassium channel activity enablesIDA PMID:7643197UniProt 
Kcnc2Ratvoltage-gated potassium channel activity enablesIDA PMID:7643197UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Kcnc2  (potassium voltage-gated channel subfamily C member 2)


Additional Information