RGD Reference Report - The potential protective role of lysophospholipid mediators in nephrotoxicity induced by chronically exposed cadmium. - Rat Genome Database

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The potential protective role of lysophospholipid mediators in nephrotoxicity induced by chronically exposed cadmium.

Authors: Tsutsumi, T  Ishihara, A  Yamamoto, A  Asaji, H  Yamakawa, S  Tokumura, A 
Citation: Tsutsumi T, etal., Food Chem Toxicol. 2014 Mar;65:52-62. doi: 10.1016/j.fct.2013.12.019. Epub 2013 Dec 20.
RGD ID: 9685430
Pubmed: PMID:24361405   (View Abstract at PubMed)
DOI: DOI:10.1016/j.fct.2013.12.019   (Journal Full-text)

Cadmium is a hazardous metal whose chronic exposure induces renal failure due to fibrosis, but the mechanisms are not well known. In this study we analyzed the molecular species of lysophosphatidic acid (LPA) and related phospholipids, together with their metabolic enzyme activity, in plasma from Wistar rats exposed up to 300ppm Cd(2+) in drinking water for 114days. Exposure of 300ppm Cd(2+) for 114days enhanced autotoxin (ATX)/lysophospholipase D activity, but significantly lowered the total levels of LPA and lysophosphatidylethanolamine. Interestingly, the total level of sphingosine-1-phosphate (S1P) was elevated dose-dependently by Cd(2+). Cultured rat kidney-derived interstitial fibroblast cells, NRK49F cells and proximal epithelial cells, NRK52E cells, were both responsive to the protective action of LPA or S1P against Cd(2+) toxicity. The former cell expresses ATX RNA. In conclusion, the elevation of LPA-producing enzyme activity and S1P concentrations in plasma after exposure of rats to Cd(2+) would protect from the renal toxicity of Cd(2+).



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ENPP2HumanCadmium Poisoning  ISOEnpp2 (Rattus norvegicus)protein:increased activity:plasma:RGD 
Enpp2RatCadmium Poisoning  IEP protein:increased activity:plasma:RGD 
Enpp2MouseCadmium Poisoning  ISOEnpp2 (Rattus norvegicus)protein:increased activity:plasma:RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Enpp2Ratcellular response to cadmium ion  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Enpp2  (ectonucleotide pyrophosphatase/phosphodiesterase 2)

Genes (Mus musculus)
Enpp2  (ectonucleotide pyrophosphatase/phosphodiesterase 2)

Genes (Homo sapiens)
ENPP2  (ectonucleotide pyrophosphatase/phosphodiesterase 2)


Additional Information