RGD Reference Report - Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. - Rat Genome Database

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Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects.

Authors: Lai, LB  Vioque, A  Kirsebom, LA  Gopalan, V 
Citation: Lai LB, etal., FEBS Lett. 2010 Jan 21;584(2):287-96. doi: 10.1016/j.febslet.2009.11.048. Epub .
RGD ID: 9685326
Pubmed: PMID:19931535   (View Abstract at PubMed)
PMCID: PMC2799185   (View Article at PubMed Central)
DOI: DOI:10.1016/j.febslet.2009.11.048   (Journal Full-text)

For an enzyme functioning predominantly in a seemingly housekeeping role of 5' tRNA maturation, RNase P displays a remarkable diversity in subunit make-up across the three domains of life. Despite the protein complexity of this ribonucleoprotein enzyme increasing dramatically from bacteria to eukarya, the catalytic function rests with the RNA subunit during evolution. However, the recent demonstration of a protein-only human mitochondrial RNase P has added further intrigue to the compositional variability of this enzyme. In this review, we discuss some possible reasons underlying the structural diversity of the active sites, and use them as thematic bases for elaborating new directions to understand how functional variations might have contributed to the complex evolution of RNase P.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
POP1HumantRNA maturation pathway  TAS  RGD 
POP4HumantRNA maturation pathway  TAS  RGD 
POP5HumantRNA maturation pathway  TAS  RGD 
POP7HumantRNA maturation pathway  TAS  RGD 
Pop1RattRNA maturation pathway  ISOPOP1 (Homo sapiens) RGD 
Pop1MousetRNA maturation pathway  ISOPOP5 (Homo sapiens) RGD 
Pop1MousetRNA maturation pathway  ISOPOP1 (Homo sapiens) RGD 
Pop1RattRNA maturation pathway  ISOPOP5 (Homo sapiens) RGD 
Pop4RattRNA maturation pathway  ISOPOP4 (Homo sapiens) RGD 
Pop4MousetRNA maturation pathway  ISOPOP4 (Homo sapiens) RGD 
Pop7RattRNA maturation pathway  ISOPOP7 (Homo sapiens) RGD 
Pop7MousetRNA maturation pathway  ISOPOP7 (Homo sapiens) RGD 
RPP14HumantRNA maturation pathway  TAS  RGD 
RPP21HumantRNA maturation pathway  TAS  RGD 
RPP25HumantRNA maturation pathway  TAS  RGD 
RPP30HumantRNA maturation pathway  TAS  RGD 
RPP38HumantRNA maturation pathway  TAS  RGD 
RPP40HumantRNA maturation pathway  TAS  RGD 
Rpp14RattRNA maturation pathway  ISORPP14 (Homo sapiens) RGD 
Rpp14MousetRNA maturation pathway  ISORPP14 (Homo sapiens) RGD 
Rpp21RattRNA maturation pathway  ISORPP21 (Homo sapiens) RGD 
Rpp21MousetRNA maturation pathway  ISORPP21 (Homo sapiens) RGD 
Rpp25RattRNA maturation pathway  ISORPP25 (Homo sapiens) RGD 
Rpp25MousetRNA maturation pathway  ISORPP25 (Homo sapiens) RGD 
Rpp30MousetRNA maturation pathway  ISORPP30 (Homo sapiens) RGD 
Rpp30RattRNA maturation pathway  ISORPP30 (Homo sapiens) RGD 
Rpp38RattRNA maturation pathway  ISORPP38 (Homo sapiens) RGD 
Rpp38MousetRNA maturation pathway  ISORPP38 (Homo sapiens) RGD 
Rpp40RattRNA maturation pathway  ISORPP40 (Homo sapiens) RGD 
Rpp40MousetRNA maturation pathway  ISORPP40 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Pop1  (POP1 homolog, ribonuclease P/MRP subunit)
Pop4  (POP4 homolog, ribonuclease P/MRP subunit)
Pop7  (POP7 homolog, ribonuclease P/MRP subunit)
Rpp14  (ribonuclease P/MRP subunit p14)
Rpp21  (ribonuclease P/MRP subunit p21)
Rpp25  (ribonuclease P and MRP subunit p25)
Rpp30  (ribonuclease P/MRP subunit p30)
Rpp38  (ribonuclease P/MRP subunit p38)
Rpp40  (ribonuclease P/MRP subunit p40)

Genes (Mus musculus)
Pop1  (processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae))
Pop4  (processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae))
Pop7  (processing of precursor 7, ribonuclease P family, (S. cerevisiae))
Rpp14  (ribonuclease P 14 subunit)
Rpp21  (ribonuclease P 21 subunit)
Rpp25  (ribonuclease P/MRP 25 subunit)
Rpp30  (ribonuclease P/MRP 30 subunit)
Rpp38  (ribonuclease P/MRP 38 subunit)
Rpp40  (ribonuclease P 40 subunit)

Genes (Homo sapiens)
POP1  (POP1 homolog, ribonuclease P/MRP subunit)
POP4  (POP4 homolog, ribonuclease P/MRP subunit)
POP5  (POP5 homolog, ribonuclease P/MRP subunit)
POP7  (POP7 homolog, ribonuclease P/MRP subunit)
RPP14  (ribonuclease P/MRP subunit p14)
RPP21  (ribonuclease P/MRP subunit p21)
RPP25  (ribonuclease P and MRP subunit p25)
RPP30  (ribonuclease P/MRP subunit p30)
RPP38  (ribonuclease P/MRP subunit p38)
RPP40  (ribonuclease P/MRP subunit p40)


Additional Information