RGD Reference Report - Cap-binding complex (CBC). - Rat Genome Database

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Cap-binding complex (CBC).

Authors: Gonatopoulos-Pournatzis, Thomas  Cowling, Victoria H 
Citation: Gonatopoulos-Pournatzis T and Cowling VH, Biochem J. 2014 Jan 15;457(2):231-42. doi: 10.1042/BJ20131214.
RGD ID: 9684851
Pubmed: PMID:24354960   (View Abstract at PubMed)
PMCID: PMC3901397   (View Article at PubMed Central)
DOI: DOI:10.1042/BJ20131214   (Journal Full-text)

The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CBC (cap-binding complex). CBC has a key role in several gene expression mechanisms, including transcription, splicing, transcript export and translation. Gene expression can be regulated by signalling pathways which influence CBC function. The aim of the present review is to discuss the mechanisms by which CBC mediates and co-ordinates multiple gene expression events.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NCBP1Human5'-end pre-mRNA capping pathway  TAS  RGD 
NCBP2Human5'-end pre-mRNA capping pathway  TAS  RGD 
Ncbp1Mouse5'-end pre-mRNA capping pathway  ISORGD:1319058 RGD 
Ncbp1Rat5'-end pre-mRNA capping pathway  ISORGD:1319058 RGD 
Ncbp2Rat5'-end pre-mRNA capping pathway  ISORGD:1313360 RGD 
Ncbp2Mouse5'-end pre-mRNA capping pathway  ISORGD:1313360 RGD 
RAMACHuman5'-end pre-mRNA capping pathway  TAS  RGD 
RNGTTHuman5'-end pre-mRNA capping pathway  TAS  RGD 
RNMTHuman5'-end pre-mRNA capping pathway  TAS  RGD 
RamacRat5'-end pre-mRNA capping pathway  ISORGD:1320685 RGD 
RngttMouse5'-end pre-mRNA capping pathway  ISORGD:1322859 RGD 
RngttRat5'-end pre-mRNA capping pathway  ISORGD:1322859 RGD 
RnmtRat5'-end pre-mRNA capping pathway  ISORGD:1319473 RGD 
RnmtMouse5'-end pre-mRNA capping pathway  ISORGD:1319473 RGD 
NCBP1HumanRNA polymerase II transcription elongation pathway  TAS  RGD 
NCBP2HumanRNA polymerase II transcription elongation pathway  TAS  RGD 
Ncbp1RatRNA polymerase II transcription elongation pathway  ISORGD:1319058 RGD 
Ncbp1MouseRNA polymerase II transcription elongation pathway  ISORGD:1319058 RGD 
Ncbp2MouseRNA polymerase II transcription elongation pathway  ISORGD:1313360 RGD 
Ncbp2RatRNA polymerase II transcription elongation pathway  ISORGD:1313360 RGD 
RNGTTHumanRNA polymerase II transcription elongation pathway  TAS  RGD 
RngttRatRNA polymerase II transcription elongation pathway  ISORGD:1322859 RGD 
RngttMouseRNA polymerase II transcription elongation pathway  ISORGD:1322859 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ncbp1  (nuclear cap binding protein subunit 1)
Ncbp2  (nuclear cap binding protein subunit 2)
Ramac  (RNA guanine-7 methyltransferase activating subunit)
Rngtt  (RNA guanylyltransferase and 5'-phosphatase)
Rnmt  (RNA (guanine-7-) methyltransferase)

Genes (Mus musculus)
Ncbp1  (nuclear cap binding protein subunit 1)
Ncbp2  (nuclear cap binding protein subunit 2)
Rngtt  (RNA guanylyltransferase and 5'-phosphatase)
Rnmt  (RNA (guanine-7-) methyltransferase)

Genes (Homo sapiens)
NCBP1  (nuclear cap binding protein subunit 1)
NCBP2  (nuclear cap binding protein subunit 2)
RAMAC  (RNA guanine-7 methyltransferase activating subunit)
RNGTT  (RNA guanylyltransferase and 5'-phosphatase)
RNMT  (RNA guanine-7 methyltransferase)


Additional Information