RGD Reference Report - The Paf1 complex: platform or player in RNA polymerase II transcription? - Rat Genome Database

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The Paf1 complex: platform or player in RNA polymerase II transcription?

Authors: Jaehning, JA 
Citation: Jaehning JA Biochim Biophys Acta. 2010 May-Jun;1799(5-6):379-88. doi: 10.1016/j.bbagrm.2010.01.001. Epub 2010 Jan 12.
RGD ID: 9588246
Pubmed: PMID:20060942   (View Abstract at PubMed)
PMCID: PMC2862274   (View Article at PubMed Central)
DOI: DOI:10.1016/j.bbagrm.2010.01.001   (Journal Full-text)

The Paf1 complex (Paf1C), composed of the proteins Paf1, Ctr9, Cdc73, Rtf1, and Leo1, accompanies RNA polymerase II (pol II) from the promoter to the 3' end formation site of mRNA and snoRNA encoding genes; it is also found associated with RNA polymerase I (pol I) on rDNA. The Paf1C is found in simple and complex eukaryotes; in human cells hSki8 is also part of the complex. The Paf1C has been linked to a large and growing list of transcription related processes including: communication with transcriptional activators; recruitment and activation of histone modification factors; facilitation of elongation on chromatin templates; and the recruitment of 3' end-processing factors necessary for accurate termination of transcription. Absence of, or mutations in, Paf1C factors result in alterations in gene expression that can result in misregulation of developmental programs and loss of control of cell division leading to cancer in humans. This review considers recent information that may help to resolve whether the Paf1C is primarily a "platform" on pol II that coordinates the association of many critical transcription factors, or if the complex itself plays a more direct role in one or more steps in transcription.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CDC73HumanRNA polymerase I transcription pathway   TAS  RGD 
CTR9HumanRNA polymerase I transcription pathway   TAS  RGD 
Cdc73RatRNA polymerase I transcription pathway   ISOCDC73 (Homo sapiens) RGD 
Cdc73MouseRNA polymerase I transcription pathway   ISOCDC73 (Homo sapiens) RGD 
Ctr9RatRNA polymerase I transcription pathway   ISOCTR9 (Homo sapiens) RGD 
Ctr9MouseRNA polymerase I transcription pathway   ISOCTR9 (Homo sapiens) RGD 
LEO1HumanRNA polymerase I transcription pathway   TAS  RGD 
Leo1RatRNA polymerase I transcription pathway   ISOLEO1 (Homo sapiens) RGD 
Leo1MouseRNA polymerase I transcription pathway   ISOLEO1 (Homo sapiens) RGD 
PAF1HumanRNA polymerase I transcription pathway   TAS  RGD 
Paf1RatRNA polymerase I transcription pathway   ISOPAF1 (Homo sapiens) RGD 
Paf1MouseRNA polymerase I transcription pathway   ISOPAF1 (Homo sapiens) RGD 
RTF1HumanRNA polymerase I transcription pathway   TAS  RGD 
Rtf1RatRNA polymerase I transcription pathway   ISORTF1 (Homo sapiens) RGD 
Rtf1MouseRNA polymerase I transcription pathway   ISORTF1 (Homo sapiens) RGD 
SKIC8HumanRNA polymerase I transcription pathway   TAS  RGD 
Skic8RatRNA polymerase I transcription pathway   ISOSKIC8 (Homo sapiens) RGD 
Skic8MouseRNA polymerase I transcription pathway   ISOSKIC8 (Homo sapiens) RGD 
CDC73HumanRNA polymerase II transcription elongation pathway  TAS  RGD 
CTR9HumanRNA polymerase II transcription elongation pathway  TAS  RGD 
Cdc73MouseRNA polymerase II transcription elongation pathway  ISOCDC73 (Homo sapiens) RGD 
Cdc73RatRNA polymerase II transcription elongation pathway  ISOCDC73 (Homo sapiens) RGD 
Ctr9MouseRNA polymerase II transcription elongation pathway  ISOCTR9 (Homo sapiens) RGD 
Ctr9RatRNA polymerase II transcription elongation pathway  ISOCTR9 (Homo sapiens) RGD 
LEO1HumanRNA polymerase II transcription elongation pathway  TAS  RGD 
Leo1MouseRNA polymerase II transcription elongation pathway  ISOLEO1 (Homo sapiens) RGD 
Leo1RatRNA polymerase II transcription elongation pathway  ISOLEO1 (Homo sapiens) RGD 
PAF1HumanRNA polymerase II transcription elongation pathway  TAS  RGD 
Paf1MouseRNA polymerase II transcription elongation pathway  ISOPAF1 (Homo sapiens) RGD 
Paf1RatRNA polymerase II transcription elongation pathway  ISOPAF1 (Homo sapiens) RGD 
RTF1HumanRNA polymerase II transcription elongation pathway  TAS  RGD 
Rtf1MouseRNA polymerase II transcription elongation pathway  ISORTF1 (Homo sapiens) RGD 
Rtf1RatRNA polymerase II transcription elongation pathway  ISORTF1 (Homo sapiens) RGD 
SKIC8HumanRNA polymerase II transcription elongation pathway  TAS  RGD 
Skic8RatRNA polymerase II transcription elongation pathway  ISOSKIC8 (Homo sapiens) RGD 
Skic8MouseRNA polymerase II transcription elongation pathway  ISOSKIC8 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Cdc73  (cell division cycle 73)
Ctr9  (CTR9 homolog, Paf1/RNA polymerase II complex component)
Leo1  (LEO1 homolog, Paf1/RNA polymerase II complex component)
Paf1  (PAF1 homolog, Paf1/RNA polymerase II complex component)
Rtf1  (Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae))
Skic8  (SKI8 subunit of superkiller complex)

Genes (Mus musculus)
Cdc73  (cell division cycle 73, Paf1/RNA polymerase II complex component)
Ctr9  (CTR9 homolog, Paf1/RNA polymerase II complex component)
Leo1  (Leo1, Paf1/RNA polymerase II complex component)
Paf1  (Paf1, RNA polymerase II complex component)
Rtf1  (RTF1, Paf1/RNA polymerase II complex component)
Skic8  (SKI8 subunit of superkiller complex)

Genes (Homo sapiens)
CDC73  (cell division cycle 73)
CTR9  (CTR9 homolog, Paf1/RNA polymerase II complex component)
LEO1  (LEO1 homolog, Paf1/RNA polymerase II complex component)
PAF1  (PAF1 homolog, Paf1/RNA polymerase II complex component)
RTF1  (RTF1 homolog, Paf1/RNA polymerase II complex component)
SKIC8  (SKI8 subunit of superkiller complex)


Additional Information