RGD Reference Report - SIRT4 prevents hypoxia-induced apoptosis in H9c2 cardiomyoblast cells. - Rat Genome Database

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SIRT4 prevents hypoxia-induced apoptosis in H9c2 cardiomyoblast cells.

Authors: Liu, B  Che, W  Xue, J  Zheng, C  Tang, K  Zhang, J  Wen, J  Xu, Y 
Citation: Liu B, etal., Cell Physiol Biochem. 2013;32(3):655-62. doi: 10.1159/000354469. Epub 2013 Sep 10.
RGD ID: 9586053
Pubmed: PMID:24029877   (View Abstract at PubMed)
DOI: DOI:10.1159/000354469   (Journal Full-text)

AIMS: Apoptosis plays a critical role in cardiomyocyte loss during ischaemic heart injury. A detailed understanding of the mechanism involved has a substantial impact on the optimization and development of treatment strategies. Here, we report that the expression of SIRT4, a mitochondrial sirtuin, is markedly down-regulated in hypoxia-induced apoptosis of H9c2 cardiomyoblast cells. METHODS AND RESULTS: SIRT4 interference significantly alters H9c2 cell viability, apoptotic cell number and caspase-3/7 activity. Furthermore, SIRT4 expression can affect the ratio of pro-caspase 9/caspase 9 or pro-caspase 3/caspase 3, an affect Bax translocation, which in turn alters the development of H9c2 cell apoptosis. CONCLUSION: These results suggest that SIRT4 is a key player in hypoxia-induced cardiomyocyte apoptosis, and that strategies based on its enhancement might be of benefit in the treatment of ischaemic heart disease.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Objects Annotated

Genes (Rattus norvegicus)
Sirt4  (sirtuin 4)


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