RGD Reference Report - Dermatitis herpetiformis--an autoimmune disease due to cross-reaction between dietary glutenin and dermal elastin? - Rat Genome Database

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Dermatitis herpetiformis--an autoimmune disease due to cross-reaction between dietary glutenin and dermal elastin?

Authors: Bodvarsson, S  Jonsdottir, I  Freysdottir, J  Leonard, JN  Fry, L  Valdimarsson, H 
Citation: Bodvarsson S, etal., Scand J Immunol. 1993 Dec;38(6):546-50.
RGD ID: 9585750
Pubmed: PMID:8256113   (View Abstract at PubMed)

Dermatitis herpetiformis (DH), is associated with skin eruptions and granular depositions of IgA in the papillary dermis, but this is not a feature of coeliac disease (CD). The specificity of the IgA in the skin is unknown. High molecular weight glutenin (HMW-g), a component of gluten, has been shown to have structural similarities to human elastin. This paper reports immunoadsorption studies which suggest that human serum may contain antibodies which cross-react with HMW-g and elastin. DH patients had significantly lower levels of IgA antibodies to HMW-g and to elastin than both CD patients and healthy controls. Furthermore, introduction of a gluten-free diet (GFD) was associated with a further reduction in the amount of IgA antibodies to elastin in the DH patients. This diet-associated decrease of elastin antibodies was restricted to the IgA isotype. A significant correlation was observed between IgA antibodies to HMW-g and elastin in healthy controls and CD patients, while no such correlation was found in patients with DH. These findings could indicate that HMW-g induces production of antibodies to elastin, which are deposited in the skin, and that when the antigenic stimulus is removed, these antibodies are further reduced due to continuous dermal deposition. It is postulated that DH may be an autoimmune disease due to cross-reactivity between dietary glutenin and dermal elastin.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ELNHumandermatitis herpetiformis  IDA  RGD 
ElnRatdermatitis herpetiformis  ISOELN (Homo sapiens) RGD 
ElnMousedermatitis herpetiformis  ISOELN (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eln  (elastin)

Genes (Mus musculus)
Eln  (elastin)

Genes (Homo sapiens)
ELN  (elastin)


Additional Information