RGD Reference Report - Postoperative atrial fibrillation is not correlated to C-reactive protein. - Rat Genome Database

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Postoperative atrial fibrillation is not correlated to C-reactive protein.

Authors: Ahlsson, AJ  Bodin, L  Lundblad, OH  Englund, AG 
Citation: Ahlsson AJ, etal., Ann Thorac Surg. 2007 Apr;83(4):1332-7.
RGD ID: 9495909
Pubmed: PMID:17383336   (View Abstract at PubMed)
DOI: DOI:10.1016/j.athoracsur.2006.11.047   (Journal Full-text)

BACKGROUND: The peak incidence of postoperative atrial fibrillation (AF) occurs around the second postoperative day, a time at which serum inflammatory markers are elevated. The aim of this study was to investigate differences between patients with and without postoperative AF with special regard to C-reactive protein (CRP) serum levels. METHODS: The study cohort included all heart surgery patients who had sinus rhythm preoperatively, survived postoperative day 3, and were operated on between July 1, 2004, and June 30, 2005 (n = 524). Any episode of AF during the first 7 postoperative days defined the patient as belonging to the postoperative AF group. Creatine kinase-myocardial band (CK-MB) was measured at postoperative day 1, and CRP was measured preoperatively and at postoperative day 3. Risk factors for postoperative AF were determined using bivariate and multivariate regression analysis. RESULTS: Of 524 patients, 182 had at least one episode of AF (34.7%). Preoperative and postoperative CRP concentrations did not differ between the groups (postoperative CRP 175.4 +/- 64.4 versus 175.3 +/- 60.1 mg/L respectively, p = 0.99). Atrial fibrillation patients were significantly older (p < 0.001) and had higher CK-MB levels (33.6 +/- 53.1 microg/L versus 22.5 +/- 26.7 microg/L, respectively, p = 0.009). The odds ratio for postoperative AF with postoperative CK-MB greater than 70 microg/L was 3.5 (confidence interval: 1.4 to 8.6). CONCLUSIONS: Postoperative AF has no correlation to the inflammatory marker CRP in heart surgery patients. Ischemic myocardial injury might predispose for postoperative AF.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CRPHumanPostoperative Atrial Fibrillation no_associationIEP  RGD 
CrpRatPostoperative Atrial Fibrillation no_associationISOCRP (Homo sapiens) RGD 
CrpMousePostoperative Atrial Fibrillation no_associationISOCRP (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crp  (C-reactive protein)

Genes (Mus musculus)
Crp  (C-reactive protein, pentraxin-related)

Genes (Homo sapiens)
CRP  (C-reactive protein)


Additional Information