RGD Reference Report - Mild obesity reduces survival and adiponectin sensitivity in endotoxemic rats. - Rat Genome Database

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Mild obesity reduces survival and adiponectin sensitivity in endotoxemic rats.

Authors: Sakai, S  Iizuka, N  Fujiwara, M  Miyoshi, M  Aoyama, M  Maeshige, N  Hamada, Y  Usami, Y  Usami, M 
Citation: Sakai S, etal., J Surg Res. 2013 Nov;185(1):353-63. doi: 10.1016/j.jss.2013.06.002. Epub 2013 Jun 25.
RGD ID: 8695926
Pubmed: PMID:23838384   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jss.2013.06.002   (Journal Full-text)

BACKGROUND: Recent meta-analyses have reported that critically ill patients with morbid obesity (body mass index >40 kg/m(2)) have poor outcomes, but the effects and mechanisms of action of mild obesity are still unclear. The purpose of this study was to evaluate the effect of mild obesity using a lard-based, high-fat diet (HFD) on pathologic conditions and the mechanisms of adiponectin action in endotoxemic rats. MATERIALS AND METHODS: Male Wistar rats underwent HFD feeding for 4 wk and were killed at 0, 1.5, and 6 h after lipopolysaccharide (LPS) injection. Plasma levels of adiponectin, nitric oxide, and interleukin 6; messenger RNA expression of adiponectin receptors (AdipoR1 and AdipoR2) in the liver and the skeletal muscle; blood biochemical test results; and histology of the liver were analyzed. RESULTS: HFD-fed rats had a lower survival rate (12.8% versus 85.2%) and lower plasma adiponectin levels after LPS injection (P < 0.01). Messenger RNA expression of adiponectin receptors in the liver, but not the skeletal muscle, also decreased in HFD-fed rats (P < 0.05). Tissue injury and oxidative stress in the liver and plasma inflammatory mediator levels increased, and worsened lipid metabolism abnormalities were noted. The findings indicated that HFD decreased the sensitivity of adiponectin and was associated with an increase in oxidative stress and inflammation, which finally resulted in worsened liver injury and poor survival rate after LPS injection. CONCLUSIONS: Short-term, HFD-induced, mild obesity is harmful to the septic host, reduces adiponectin sensitivity, and could be the cause of worsening pathologic conditions.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADIPOR2HumanChemical and Drug Induced Liver Injury severityISOAdipor2 (Rattus norvegicus)associated with obesity more ...RGD 
Adipor2RatChemical and Drug Induced Liver Injury severityIEP associated with obesity more ...RGD 
Adipor2MouseChemical and Drug Induced Liver Injury severityISOAdipor2 (Rattus norvegicus)associated with obesity more ...RGD 
ADIPOQHumanEndotoxemia  ISOAdipoq (Rattus norvegicus)associated with ObesityRGD 
ADIPOR2HumanEndotoxemia severityISOAdipor2 (Rattus norvegicus)associated with obesity and mRNA:decreased expression:liver (rat)RGD 
AdipoqRatEndotoxemia  IEP associated with ObesityRGD 
AdipoqMouseEndotoxemia  ISOAdipoq (Rattus norvegicus)associated with ObesityRGD 
Adipor2RatEndotoxemia severityIEP associated with obesity and mRNA:decreased expression:liver (rat)RGD 
Adipor2MouseEndotoxemia severityISOAdipor2 (Rattus norvegicus)associated with obesity and mRNA:decreased expression:liver (rat)RGD 
ADIPOR2Humanobesity severityISOAdipor2 (Rattus norvegicus)mRNA:decreased expression:liver (rat)RGD 
Adipor2Ratobesity severityIEP mRNA:decreased expression:liver (rat)RGD 
Adipor2Mouseobesity severityISOAdipor2 (Rattus norvegicus)mRNA:decreased expression:liver (rat)RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADIPOR2Humanlipopolysaccharide decreases expression ISOAdipor2 (Rattus norvegicus)lipopolysaccharide decreases expression of adipor2 mRNA in obese rat liverRGD 
Adipor2Ratlipopolysaccharide decreases expression EXP lipopolysaccharide decreases expression of adipor2 mRNA in obese rat liverRGD 
Adipor2Mouselipopolysaccharide decreases expression ISOAdipor2 (Rattus norvegicus)lipopolysaccharide decreases expression of adipor2 mRNA in obese rat liverRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Adipor2Ratresponse to ethanol  IEP  RGD 
Adipor2Ratresponse to lipopolysaccharide  IEP  RGD 
Adipor2Ratresponse to nutrient levels  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)
Adipor2  (adiponectin receptor 2)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)
Adipor2  (adiponectin receptor 2)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)
ADIPOR2  (adiponectin receptor 2)


Additional Information