RGD Reference Report - Quantitative Trait Loci Influencing Abdominal Fat Deposition and Functional Variability of the HPA Axis in the Rat. - Rat Genome Database

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Quantitative Trait Loci Influencing Abdominal Fat Deposition and Functional Variability of the HPA Axis in the Rat.

Authors: Marissal-Arvy, N  Helies, JM  Tridon, C  Moisan, MP  Mormede, P 
Citation: Marissal-Arvy N, etal., Horm Metab Res. 2014 Jul 8.
RGD ID: 8694157
Pubmed: (View Article at PubMed) PMID:25003539
DOI: Full-text: DOI:10.1055/s-0034-1383574

With the aim to reveal common genomic regions influencing phenotypes related to HPA axis function and metabolism, we did a quantitative trait loci (QTL) study in a F2 population obtained from the cross-breeding between 2 contrasted rat strains, LOU/C and Fischer 344. QTL determining phenotypes related first to corticotropic function were searched: plasma corticosterone (Cort) in control and stress conditions, after a dexamethasone suppression treatment (glucocorticoid receptor related-effect), and mineralocorticoid receptor-mediated urinary response to aldosterone. Then, phenotypes related to metabolism were studied on the same animals: body composition, basal and post-insulin plasma glucose, plasma free fatty acids, leptin, and insulin. Finally, we analyzed the overlapping regions between these QTL and looked for candidate genes within these regions. The gene NR3C1 encoding the glucocorticoid receptor was confirmed to be central in the link between hypothalamic-pituitary-adrenal (HPA) axis function and fat deposition, and its metabolic consequences. Among the other candidate genes detected, most contain a glucocorticoid responsive element, strengthening our hypothesis of common genetic determinism between HPA axis and metabolism.

Annotation

Disease Annotations    

Objects Annotated

QTLs
Abfw1  (Abdominal fat weight QTL 1)
Abfw2  (Abdominal fat weight QTL 2)
Abfw3  (Abdominal fat weight QTL 3)
Abfw4  (Abdominal fat weight QTL 4)
Abfw5  (Abdominal fat weight QTL 5)
Abfw6  (Abdominal fat weight QTL 6)
Abfw7  (Abdominal fat weight QTL 7)
Abfw8  (Abdominal fat weight QTL 8)
Bw147  (Body weight QTL 147)
Bw148  (Body weight QTL 148)
Bw149  (Body weight QTL 149)
Bw150  (Body weight QTL 150)
Bw151  (Body weight QTL 151)
Bw152  (Body weight QTL 152)
Bw153  (Body weight QTL 153)
Bw154  (Body weight QTL 154)
Bw155  (Body weight QTL 155)
Bw156  (Body weight QTL 156)
Bw157  (Body weight QTL 157)
Bw158  (Body weight QTL 158)
Bw159  (Body weight QTL 159)
Bw160  (Body weight QTL 160)
Bw161  (Body weight QTL 161)
Bw162  (Body weight QTL 162)
Bw163  (Body weight QTL 163)
Bw164  (Body weight QTL 164)
Bw165  (Body weight QTL 165)
Bw166  (Body weight QTL 166)
Bw167  (Body weight QTL 167)
Bw168  (Body weight QTL 168)
Bw169  (Body weight QTL 169)
Bw170  (Body weight QTL 170)
Bw171  (Body weight QTL 171)
Bw172  (Body weight QTL 172)
Epfw10  (Epididymal fat weight QTL 10)
Epfw11  (Epididymal fat weight QTL 11)
Epfw12  (Epididymal fat weight QTL 12)
Epfw6  (Epididymal fat weight QTL 6)
Epfw7  (Epididymal fat weight QTL 7)
Epfw8  (Epididymal fat weight QTL 8)
Epfw9  (Epididymal fat weight QTL 9)
Gluco65  (Glucose level QTL 65)
Gluco66  (Glucose level QTL 66)
Gluco67  (Glucose level QTL 67)
Gluco68  (Glucose level QTL 68)
Insglur3  (Insulin/glucose ratio QTL 3)
Insglur4  (Insulin/glucose ratio QTL 4)
Insglur5  (Insulin/glucose ratio QTL 5)
Insglur6  (Insulin/glucose ratio QTL 6)
Insglur7  (Insulin/glucose ratio QTL 7)
Insglur8  (Insulin/glucose ratio QTL 8)
Insglur9  (Insulin/glucose ratio QTL 9)
Insul23  (Insulin level QTL 23)
Insul24  (Insulin level QTL 24)
Insul25  (Insulin level QTL 25)
Insul26  (Insulin level QTL 26)
Insul27  (Insulin level QTL 27)
Insul28  (Insulin level QTL 28)
Insul29  (Insulin level QTL 29)
Insul30  (Insulin level QTL 30)
Insul31  (Insulin level QTL 31)
Insul32  (Insulin level QTL 32)
Scfw1  (Subcutaneous fat weight QTL 1)
Scfw2  (Subcutaneous fat weight QTL 2)
Scfw3  (Subcutaneous fat weight QTL 3)
Scfw4  (Subcutaneous fat weight QTL 4)
Scfw5  (Subcutaneous fat weight QTL 5)
Scfw6  (Subcutaneous fat weight QTL 6)
Scort10  (Serum corticosterone level QTL 10)
Scort11  (Serum corticosterone level QTL 11)
Scort12  (Serum corticosterone level QTL 12)
Scort13  (Serum corticosterone level QTL 13)
Scort14  (Serum corticosterone level QTL 14)
Scort15  (Serum corticosterone level QTL 15)
Scort16  (Serum corticosterone level QTL 16)
Scort17  (Serum corticosterone level QTL 17)
Scort18  (Serum corticosterone level QTL 18)
Scort19  (Serum corticosterone level QTL 19)
Scort20  (Serum corticosterone level QTL 20)
Scort21  (Serum corticosterone level QTL 21)
Scort22  (Serum corticosterone level QTL 22)
Scort3  (Serum corticosterone level QTL 3)
Scort4  (Serum corticosterone level QTL 4)
Scort5  (Serum corticosterone level QTL 5)
Scort6  (Serum corticosterone level QTL 6)
Scort7  (Serum corticosterone level QTL 7)
Scort8  (Serum corticosterone level QTL 8)
Scort9  (Serum corticosterone level QTL 9)
Sffal3  (Serum free fatty acids level QTL 3)
Sffal4  (Serum free fatty acids level QTL 4)
Sffal5  (Serum free fatty acids level QTL 5)
Sffal6  (Serum free fatty acids level QTL 6)
Sffal7  (Serum free fatty acids level QTL 7)
Sffal8  (Serum free fatty acids level QTL 8)
Slep10  (Serum leptin concentration QTL 10)
Slep11  (Serum leptin concentration QTL 11)
Slep12  (Serum leptin concentration QTL 12)
Slep13  (Serum leptin concentration QTL 13)
Uminl1  (Urine mineral level QTL 1)
Uminl2  (Urine mineral level QTL 2)
Uminl3  (Urine mineral level QTL 3)
Uminl4  (Urine mineral level QTL 4)
Uminl5  (Urine mineral level QTL 5)

Objects referenced in this article
Strain F344/IcoCrlf null Rattus norvegicus
Strain LOU/NimrOlaHsd Louvain Rattus norvegicus

Additional Information