RGD Reference Report - Resistance of MBL gene-knockout mice to experimental systemic aspergillosis. - Rat Genome Database

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Resistance of MBL gene-knockout mice to experimental systemic aspergillosis.

Authors: Clemons, KV  Martinez, M  Tong, AJ  Stevens, DA 
Citation: Clemons KV, etal., Immunol Lett. 2010 Feb 16;128(2):105-7. doi: 10.1016/j.imlet.2009.12.021. Epub 2010 Jan 12.
RGD ID: 8694071
Pubmed: PMID:20064561   (View Abstract at PubMed)
DOI: DOI:10.1016/j.imlet.2009.12.021   (Journal Full-text)

Mannose binding lectin (MBL) is a protein of the collectin family that appears important in resistance to invasive pulmonary aspergillosis. We assessed the role of MBL in experimental systemic aspergillosis. MBL-sufficient C57BL/6 (WT) mice and B6.129S4--Mb11(tm1Kata) Mb12(tm1Kata)/J MBL A and C gene-knockout (KO) mice were infected intravenously with different inocula of Aspergillus fumigatus conidia. WT and KO mice were dose-responsively susceptible. In no instance were the KO mice more susceptible than WT. At the highest inoculum, all WT and 90% of KO mice died on day 4 (P>0.05). Reduction of the inoculum to 5.5 x 10(6) conidia was lethal, but comparison showed KO mice less susceptible to lethal infection (P<0.015). At the lowest inoculum used, deaths of KO mice were delayed, but survival was not significantly different than WT (P>0.05). These results suggest MBL may play a deleterious role in systemic aspergillosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MBL2Humanaspergillosis susceptibilityISOMbl2 (Mus musculus) RGD 
Mbl1Rataspergillosis susceptibilityISOMbl1 (Mus musculus) RGD 
Mbl1Mouseaspergillosis susceptibilityIMP  RGD 
Mbl2Rataspergillosis susceptibilityISOMbl2 (Mus musculus) RGD 
Mbl2Mouseaspergillosis susceptibilityIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl1  (mannose binding lectin 1)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl1  (mannose-binding lectin (protein A) 1)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information