RGD Reference Report - Involvement of mannose-binding lectin in the pathogenesis of Kawasaki disease-like murine vasculitis. - Rat Genome Database

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Involvement of mannose-binding lectin in the pathogenesis of Kawasaki disease-like murine vasculitis.

Authors: Nakamura, A  Okigaki, M  Miura, N  Suzuki, C  Ohno, N  Kametani, F  Hamaoka, K 
Citation: Nakamura A, etal., Clin Immunol. 2014 Jul;153(1):64-72. doi: 10.1016/j.clim.2014.03.019. Epub 2014 Apr 8.
RGD ID: 8693744
Pubmed: PMID:24721319   (View Abstract at PubMed)
DOI: DOI:10.1016/j.clim.2014.03.019   (Journal Full-text)

Kawasaki disease (KD) is a paediatric idiopathic vasculitis. In this study, on the basis of studies using an established animal model for KD, we report that mannose-binding lectin (MBL) is involved in the pathogenesis of the disease. KD-like experimental murine vasculitis was induced by intraperitoneally administering a Candida albicans water-soluble extract (CAWS). MBL-A gradually increased in the serum of the model mice treated with CAWS. Deposition of MBL-A and MBL-C was observed in the aortic root, including the coronary arteries, which is a predilection site in experimental vasculitis. Corresponding to the distribution patterns of MBLs, marked deposition of C3/C3-derived peptides was also observed. Regarding the self-reactivity of MBLs, we observed that MBLs interacted with core histones to activate the lectin pathway. These results suggest that some types of pathogens provoke the MBL-dependent complement pathway (lectin pathway) to cause and/or exacerbate KD-like vasculitis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MBL2HumanKawasaki disease  ISOMbl2 (Mus musculus) RGD 
Mbl1RatKawasaki disease  ISOMbl1 (Mus musculus) RGD 
Mbl1MouseKawasaki disease  IEP  RGD 
Mbl2RatKawasaki disease  ISOMbl2 (Mus musculus) RGD 
Mbl2MouseKawasaki disease  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl1  (mannose binding lectin 1)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl1  (mannose-binding lectin (protein A) 1)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information