RGD Reference Report - Mannan-binding lectin modulates the response to HSV-2 infection. - Rat Genome Database

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Mannan-binding lectin modulates the response to HSV-2 infection.

Authors: Gadjeva, M  Paludan, SR  Thiel, S  Slavov, V  Ruseva, M  Eriksson, K  Lowhagen, GB  Shi, L  Takahashi, K  Ezekowitz, A  Jensenius, JC 
Citation: Gadjeva M, etal., Clin Exp Immunol. 2004 Nov;138(2):304-11.
RGD ID: 8693727
Pubmed: PMID:15498041   (View Abstract at PubMed)
PMCID: PMC1809223   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1365-2249.2004.02616.x   (Journal Full-text)

Viruses have developed numerous strategies to escape recognition by the immune system. However, some viruses such as herpes simplex virus-2 (HSV-2) are recognized by initiators of the complement system, e.g. mannan-binding lectin (MBL). To study the effects of MBL deficiency during viral infection we have chosen a model of generalized HSV-2 infection. We infected MBL-A and MBL-C double knock-out mice (DKO) with HSV-2 via the intraperitoneal (i.p.) route. DKO mice cleared HSV-2 from the liver less efficiently than the comparable wild-type animals. The impairment to effectively neutralize HSV-2 correlated with compromised liver function as measured by increased plasma levels of alanine-amino transferase. No differences in the viral burden were found in other organs such as spleen or brain. Thus, MBL-mediated protection was limited to the effects of preservation of liver homeostasis. Reconstitution with recombinant human MBL before and during the HSV-2 infection dramatically lowered the viral titres in the liver. Taken together, the data show that MBL modulates the response to HSV-2 in mice by affecting neutralization of the virus. To analyse if MBL plays a role in establishment and progression of human HSV-2 infection we analysed MBL levels in the serum samples from asymptomatic (virus-exposed people who have never displayed symptoms of HSV-2 infection) and symptomatic HSV-2 patients (people with recurrent HSV-2 infections). We found that the frequency of the MBL deficiency (<100 ng/ml) was higher in the symptomatic group and significantly different from that in the asymptomatic group (P = 0.0369). This suggests that lack of MBL-mediated complement activation increases susceptibility to viral infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MBL2Humanherpes simplex disease_progressionIEP  RGD 
MBL2Humanherpes simplex  IDA  RGD 
Mbl1Ratherpes simplex  ISOMbl1 (Mus musculus)protein:increased expression:serum:RGD 
Mbl1Mouseherpes simplex  IEP protein:increased expression:serum:RGD 
Mbl2Ratherpes simplex disease_progressionISOMBL2 (Homo sapiens) RGD 
Mbl2Ratherpes simplex  ISOMBL2 (Homo sapiens) RGD 
Mbl2Mouseherpes simplex disease_progressionISOMBL2 (Homo sapiens) RGD 
Mbl2Mouseherpes simplex  ISOMBL2 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl1  (mannose binding lectin 1)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl1  (mannose-binding lectin (protein A) 1)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information