RGD Reference Report - Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection. - Rat Genome Database

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Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection.

Authors: Seppanen, M  Lokki, ML  Lappalainen, M  Hiltunen-Back, E  Rovio, AT  Kares, S  Hurme, M  Aittoniemi, J 
Citation: Seppanen M, etal., Hum Immunol. 2009 Apr;70(4):218-21. doi: 10.1016/j.humimm.2009.01.022. Epub 2009 Feb 4.
RGD ID: 8693725
Pubmed: PMID:19480845   (View Abstract at PubMed)
DOI: DOI:10.1016/j.humimm.2009.01.022   (Journal Full-text)

Mannose-binding lectin (MBL) is a complement component and an opsonic factor recognizing and binding to herpes simplex virus 2 (HSV-2). In this study, we assessed the effect of MBL2 genotypes on the risk of recurring HSV-2 infection. The MBL2 structural variant genotype (A/O or O/O) was more common among the patients with recurrent HSV-2 infection compared with healthy controls (47% vs 26%, respectively; odds ratio [OR] = 2.6, 95% confidence interval [CI] 1.3-4.9; p = 0.005) or controls positive for HSV-2 antibodies (15%; OR 4.9, 95% CI 1.5-16; p = 0.007). Thus, we conclude that the MBL2 structural variant genotype, possibly through impaired recognition of HSV-2, seems to predispose individuals to the development of recurring HSV-2 infection.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MBL2Humanherpes simplex susceptibilityIAGP DNA:polymorphism:cds:RGD 
Mbl2Ratherpes simplex susceptibilityISOMBL2 (Homo sapiens)DNA:polymorphism:cds:RGD 
Mbl2Mouseherpes simplex susceptibilityISOMBL2 (Homo sapiens)DNA:polymorphism:cds:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information