RGD Reference Report - Levels of soluble Fas/APO-1 in patients with Behcet's disease. - Rat Genome Database

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Levels of soluble Fas/APO-1 in patients with Behcet's disease.

Authors: Hamzaoui, K  Hamzaoui, A  Zakraoui, L  Chabbou, A 
Citation: Hamzaoui K, etal., Mediators Inflamm. 1998;7(2):111-4.
RGD ID: 8662438
Pubmed: PMID:9836498   (View Abstract at PubMed)
PMCID: PMC1781828   (View Article at PubMed Central)
DOI: DOI:10.1080/09629359891261   (Journal Full-text)

The aim of this study was to quantify soluble Fas/APO-1 (sFas/APO-1) protein in the serum of patients with Behcet's disease (BD) in active and inactive stages, compared with patients with systemic lupus erythematosus (SLE) and patients with rheumatoid arthritis (RA). Soluble Fas/APO-1 was quantified using a sandwich enzyme-linked immunosorbent assay. Increased serum sFas/APO-1 levels were observed in active BD, compared with inactive BD, RA patients and SLE patients. Increased serum sFas/APO-1 levels were correlated with the presence of neurologic manifestations or pulmonary involvement in active BD. In conclusion, increased levels of sFas/APO-1 occurred frequently and exclusively in active BD patients. Preliminary evidence suggested that elevated levels of sFas/APO-1 are associated with the clinical stage and clinical manifestations in BD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Behcet's disease severityIEP 8662438protein:increased expression:serum (human)RGD 
Behcet's disease severityISOFAS (Homo sapiens)8662438; 8662438protein:increased expression:serum (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fas  (Fas cell surface death receptor)

Genes (Mus musculus)
Fas  (Fas cell surface death receptor)

Genes (Homo sapiens)
FAS  (Fas cell surface death receptor)

Additional Information