RGD Reference Report - Prevalence of human papillomavirus, Epstein-Barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in Hong Kong patients. - Rat Genome Database

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Prevalence of human papillomavirus, Epstein-Barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in Hong Kong patients.

Authors: Sham, CL  To, KF  Chan, PK  Lee, DL  Tong, MC  Van Hasselt, CA 
Citation: Sham CL, etal., Head Neck. 2012 Apr;34(4):520-33. doi: 10.1002/hed.21772. Epub 2011 May 23.
RGD ID: 8662357
Pubmed: PMID:21608063   (View Abstract at PubMed)
DOI: DOI:10.1002/hed.21772   (Journal Full-text)

BACKGROUND: The purpose of this study of human papillomavirus (HPV), Epstein-Barr virus (EBV), p21, and p53 in sinonasal inverted papilloma (IP) was to help elucidate its pathogenesis. METHODS: Seventy-three IPs, 48 nasal polyps, and 85 hypertrophied turbinates were subjected to HPV polymerase chain reaction (PCR) study. Seventy-three IPs, 30 nasal polyps, and 32 hypertrophied turbinates were subjected to EBV in situ hybridization (ISH), p21, and p53 immunohistochemical (IHC) studies. RESULTS: HPV was positive in 3 of 73 IPs (4.1%). All specimens were EBV negative. In all, 99% of IPs showed strong and diffuse p21 nuclear reactivity. Most nasal polyps and hypertrophied turbinates showed weak to moderate immunoreactivity of the basal and parabasal cells. Only focal p53 immunoreactivity of the basal and parabasal cells was found in 19% of IPs and 40% of nasal polyps. CONCLUSIONS: HPV prevalence of our IP is low. EBV is not present in IP. High p21 and low p53 expression in IP suggests a non-p53-dependent regulation pathway.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CDKN1AHumaninverted papilloma  IEP protein:increased expression:nucleus:RGD 
Cdkn1aRatinverted papilloma  ISOCDKN1A (Homo sapiens)protein:increased expression:nucleus:RGD 
Cdkn1aMouseinverted papilloma  ISOCDKN1A (Homo sapiens)protein:increased expression:nucleus:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn1a  (cyclin-dependent kinase inhibitor 1A)

Genes (Mus musculus)
Cdkn1a  (cyclin dependent kinase inhibitor 1A)

Genes (Homo sapiens)
CDKN1A  (cyclin dependent kinase inhibitor 1A)


Additional Information