RGD Reference Report - ATM protein kinase: the linchpin of cellular defenses to stress. - Rat Genome Database

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ATM protein kinase: the linchpin of cellular defenses to stress.

Authors: Bhatti, S  Kozlov, S  Farooqi, AA  Naqi, A  Lavin, M  Khanna, KK 
Citation: Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
RGD ID: 8661232
Pubmed: PMID:21533982   (View Abstract at PubMed)
DOI: DOI:10.1007/s00018-011-0683-9   (Journal Full-text)

ATM is the most significant molecule involved in monitoring the genomic integrity of the cell. Any damage done to DNA relentlessly challenges the cellular machinery involved in recognition, processing and repair of these insults. ATM kinase is activated early to detect and signal lesions in DNA, arrest the cell cycle, establish DNA repair signaling and faithfully restore the damaged chromatin. ATM activation plays an important role as a barrier to tumorigenesis, metabolic syndrome and neurodegeneration. Therefore, studies of ATM-dependent DNA damage signaling pathways hold promise for treatment of a variety of debilitating diseases through the development of new therapeutics capable of modulating cellular responses to stress. In this review, we have tried to untangle the complex web of ATM signaling pathways with the purpose of pinpointing multiple roles of ATM underlying the complex phenotypes observed in AT patients.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ATMHumanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
AtmMouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1606040 RGD 
AtmRatataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1606040 RGD 
H2AXHumanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
H2axMouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1346464 RGD 
H2axRatataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1346464 RGD 
KAT5Humanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
Kat5Ratataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:732354 RGD 
Kat5Mouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:732354 RGD 
MDC1Humanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
MRE11Humanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
Mdc1Mouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1348817 RGD 
Mdc1Ratataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1348817 RGD 
Mre11Ratataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1344886 RGD 
Mre11aMouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1344886 RGD 
NBNHumanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
NbnRatataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1348611 RGD 
NbnMouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1348611 RGD 
PPM1DHumanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
PPP2CAHumanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
PPP5CHumanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
Ppm1dRatataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1313498 RGD 
Ppm1dMouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1313498 RGD 
Ppp2caRatataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:735585 RGD 
Ppp2caMouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:735585 RGD 
Ppp5cRatataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:68614 RGD 
Ppp5cMouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:68614 RGD 
RAD50Humanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
RNF168Humanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
RNF8Humanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
Rad50Ratataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:722899 RGD 
Rad50Mouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:722899 RGD 
Rnf168Ratataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1347950 RGD 
Rnf168Mouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1347950 RGD 
Rnf8Ratataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1317571 RGD 
Rnf8Mouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1317571 RGD 
UBE2NHumanataxia telangiectasia-mutated (ATM) signaling pathway   TAS  RGD 
Ube2nRatataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1348630 RGD 
Ube2nMouseataxia telangiectasia-mutated (ATM) signaling pathway   ISORGD:1348630 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Atm  (ATM serine/threonine kinase)
H2ax  (H2A.X variant histone)
Kat5  (lysine acetyltransferase 5)
Mdc1  (mediator of DNA damage checkpoint 1)
Mre11  (MRE11 homolog, double strand break repair nuclease)
Nbn  (nibrin)
Ppm1d  (protein phosphatase, Mg2+/Mn2+ dependent, 1D)
Ppp2ca  (protein phosphatase 2 catalytic subunit alpha)
Ppp5c  (protein phosphatase 5, catalytic subunit)
Rad50  (RAD50 double strand break repair protein)
Rnf168  (ring finger protein 168)
Rnf8  (ring finger protein 8)
Ube2n  (ubiquitin-conjugating enzyme E2N)

Genes (Mus musculus)
Atm  (ataxia telangiectasia mutated)
H2ax  (H2A.X variant histone)
Kat5  (K(lysine) acetyltransferase 5)
Mdc1  (mediator of DNA damage checkpoint 1)
Mre11a  (MRE11A homolog A, double strand break repair nuclease)
Nbn  (nibrin)
Ppm1d  (protein phosphatase 1D magnesium-dependent, delta isoform)
Ppp2ca  (protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform)
Ppp5c  (protein phosphatase 5, catalytic subunit)
Rad50  (RAD50 double strand break repair protein)
Rnf168  (ring finger protein 168)
Rnf8  (ring finger protein 8)
Ube2n  (ubiquitin-conjugating enzyme E2N)

Genes (Homo sapiens)
ATM  (ATM serine/threonine kinase)
H2AX  (H2A.X variant histone)
KAT5  (lysine acetyltransferase 5)
MDC1  (mediator of DNA damage checkpoint 1)
MRE11  (MRE11 homolog, double strand break repair nuclease)
NBN  (nibrin)
PPM1D  (protein phosphatase, Mg2+/Mn2+ dependent 1D)
PPP2CA  (protein phosphatase 2 catalytic subunit alpha)
PPP5C  (protein phosphatase 5 catalytic subunit)
RAD50  (RAD50 double strand break repair protein)
RNF168  (ring finger protein 168)
RNF8  (ring finger protein 8)
UBE2N  (ubiquitin conjugating enzyme E2 N)


Additional Information