RGD Reference Report - Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis.

Authors: Shimizu, M  Yokoyama, T  Yamada, K  Kaneda, H  Wada, H  Wada, T  Toma, T  Ohta, K  Kasahara, Y  Yachie, A 
Citation: Shimizu M, etal., Rheumatology (Oxford). 2010 Sep;49(9):1645-53. doi: 10.1093/rheumatology/keq133. Epub 2010 May 14.
RGD ID: 8655917
Pubmed: PMID:20472718   (View Abstract at PubMed)
DOI: DOI:10.1093/rheumatology/keq133   (Journal Full-text)

OBJECTIVES: To compare the pro-inflammatory cytokine profiles and the cytokine kinetics in patients with secondary macrophage activation syndrome (MAS) due to systemic-onset juvenile idiopathic arthritis (s-JIA) and in both active and inactive disease states of s-JIA (but no MAS), with those demonstrated in EBV-induced haemophagocytic lymphohistiocytosis (HLH) and Kawasaki disease (KD), and to investigate the significance of IL-18 in the pathogenesis of s-JIA. METHODS: Five patients with MAS complicating s-JIA (MAS/s-JIA), 10 with HLH due to EBV infection (EBV-HLH), 22 with KD and 28 healthy controls were analysed. Cytokine concentrations (IL-18, IL-6, neopterin and TNF-alpha receptor Types I and II) were quantified in serum by ELISA. Results were compared with clinical features of MAS/s-JIA, including ferritin concentrations. RESULTS: Serum IL-18 concentrations in MAS/s-JIA patients were significantly higher than those in EBV-HLH or KD patients (P < 0.05). Serum IL-6 concentrations in KD patients were significantly higher than those in EBV-HLH or MAS/s-JIA patients. Serum neopterin concentrations in EBV-HLH patients were significantly higher than those in MAS/s-JIA or KD patients. Serum IL-18 correlated positively with the following measurements of disease activity: CRP, ferritin, lactate dehydrogenase and other cytokines (P < 0.05). Serum concentrations of IL-18 in s-JIA patients remained elevated in the inactive phase of disease, whereas clinical parameters and other cytokines normalized. CONCLUSIONS: IL-18 may be an important mediator in s-JIA. Although serum Il-18 concentrations correlated with markers of the disease activity, IL-18 concentrations remained elevated even when other markers of disease activity normalized. Serum IL-18 concentration may be a promising indicator of the disease activity. The cytokine release pattern in MAS/HLH is different among patients with different aetiologies. Monitoring the cytokine profile, including IL-18, may be useful for differentiation of MAS/HLH and evaluation of disease activity in s-JIA.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL18Humanhemophagocytic lymphohistiocytosis  IEP associated with Epstein-Barr Virus Infections and protein:increased expression:serumRGD 
Il18Rathemophagocytic lymphohistiocytosis  ISOIL18 (Homo sapiens)associated with Epstein-Barr Virus Infections and protein:increased expression:serumRGD 
Il18Mousehemophagocytic lymphohistiocytosis  ISOIL18 (Homo sapiens)associated with Epstein-Barr Virus Infections and protein:increased expression:serumRGD 
IL18HumanMacrophage Activation Syndrome  IEP associated with Arthritis more ...RGD 
Il18RatMacrophage Activation Syndrome  ISOIL18 (Homo sapiens)associated with Arthritis more ...RGD 
Il18MouseMacrophage Activation Syndrome  ISOIL18 (Homo sapiens)associated with Arthritis more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il18  (interleukin 18)

Genes (Mus musculus)
Il18  (interleukin 18)

Genes (Homo sapiens)
IL18  (interleukin 18)


Additional Information