RGD Reference Report - Bax inserts into the mitochondrial outer membrane by different mechanisms. - Rat Genome Database

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Bax inserts into the mitochondrial outer membrane by different mechanisms.

Authors: Cartron, PF  Bellot, G  Oliver, L  Grandier-Vazeille, X  Manon, S  Vallette, FM 
Citation: Cartron PF, etal., FEBS Lett. 2008 Sep 3;582(20):3045-51. doi: 10.1016/j.febslet.2008.07.047. Epub 2008 Aug 5.
RGD ID: 8554729
Pubmed: PMID:18687331   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2008.07.047   (Journal Full-text)

Bax insertion into the mitochondrial outer membrane is essential for the implementation of apoptosis. However, little is known about the first stage of Bax integration into the mitochondrial outer membrane. We have recently shown that TOM22, a mitochondrial outer membrane receptor, is important for insertion, although other reports have suggested that only mitochondrial lipids are involved in this process. Here, we show that monomers, but not dimers, of Bax require the presence of TOM22 and TOM40 to integrate into mitochondria. In addition we show that once inserted into the membrane, Bax can act as a receptor for cytosolic Bax.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Tomm22Ratprotein transmembrane transporter activity enablesIMP PMID:18687331BHF-UCL 
Tomm40Ratprotein transmembrane transporter activity enablesIMP PMID:18687331BHF-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Tomm22  (translocase of outer mitochondrial membrane 22)
Tomm40  (translocase of outer mitochondrial membrane 40)


Additional Information