RGD Reference Report - NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. - Rat Genome Database

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NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex.

Authors: Sans, N  Prybylowski, K  Petralia, RS  Chang, K  Wang, YX  Racca, C  Vicini, S  Wenthold, RJ 
Citation: Sans N, etal., Nat Cell Biol. 2003 Jun;5(6):520-30.
RGD ID: 8554028
Pubmed: PMID:12738960   (View Abstract at PubMed)
DOI: DOI:10.1038/ncb990   (Journal Full-text)

NMDA (N-methyl-D-aspartate) receptors (NMDARs) are targeted to dendrites and anchored at the post-synaptic density (PSD) through interactions with PDZ proteins. However, little is known about how these receptors are sorted from the endoplasmic reticulum and Golgi apparatus to the synapse. Here, we find that synapse-associated protein 102 (SAP102) interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. Our results show that interactions between SAP102 and Sec8 are involved in the delivery of NMDARs to the cell surface in heterologous cells and neurons. Furthermore, they suggest that an exocyst-SAP102-NMDAR complex is an important component of NMDAR trafficking.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Dlg3Ratdendritic shaft located_inIDA PMID:12738960UniProt 
Exoc4Ratdendritic shaft located_inIDA PMID:12738960UniProt 
Exoc4Ratexocyst part_ofTAS PMID:12738960UniProt 
Dlg3Ratgrowth cone located_inIDA PMID:12738960UniProt 
Exoc4Ratgrowth cone located_inIDA PMID:12738960UniProt 
Exoc4Ratneuron projection located_inIDA PMID:12738960UniProt 
Grin2aRatneuron projection located_inIDA PMID:12738960UniProt 
Grin2bRatneuron projection located_inIDA PMID:12738960UniProt 
Dlg3Ratneuronal cell body located_inIDA PMID:12738960UniProt 
Exoc4Ratneuronal cell body located_inIDA PMID:12738960UniProt 
Dlg3Ratpostsynaptic density located_inIDA PMID:12738960UniProt 
Exoc4Ratpostsynaptic density located_inIDA PMID:12738960UniProt 
Exoc4Ratpostsynaptic density, intracellular component is_active_inIDA PMID:12738960SynGO 
Exoc4RatSchaffer collateral - CA1 synapse is_active_inIDA PMID:12738960SynGO 
Dlg3Ratsynapse located_inIDA PMID:12738960UniProt 
Exoc4Ratsynapse located_inIDA PMID:12738960UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Exoc4RatPDZ domain binding enablesIPIUniProtKB:Q62936PMID:12738960UniProt 
Dlg3Ratprotein binding enablesIPIUniProtKB:Q62824PMID:12738960UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Dlg3  (discs large MAGUK scaffold protein 3)
Exoc4  (exocyst complex component 4)
Grin2a  (glutamate ionotropic receptor NMDA type subunit 2A)
Grin2b  (glutamate ionotropic receptor NMDA type subunit 2B)


Additional Information