RGD Reference Report - The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. - Rat Genome Database

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The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.

Authors: Hellgren, G  Jansson, JO  Carlsson, LM  Carlsson, B 
Citation: Hellgren G, etal., Growth Horm IGF Res. 1999 Jun;9(3):212-8.
RGD ID: 8553995
Pubmed: PMID:10502458   (View Abstract at PubMed)
DOI: DOI:10.1054/ghir.1999.0111   (Journal Full-text)

Studies in cell lines have shown that Jak2 is the primary tyrosine kinase involved in signal transduction by the growth hormone receptor (GHR). In addition, growth hormone (GH) stimulates tyrosine phosphorylation of Jak1 and Jak3 in certain cell lines, while the effect on Tyk2 has not been analysed. We have investigated the expression of Jak proteins in human liver and analysed their interactions with the GHR. Using Western blot analysis and immunohistochemistry, we demonstrate that Jak1, Jak2, Jak3 and Tyk2 are present in human liver. Immunoprecipitation by an antibody against the GHR (Mab 263) followed by immunoblotting with specific antibodies against Jak proteins showed that Jak1, Jak2 and Tyk2 were associated with the GHR in this tissue. We conclude that the GHR associates with Jak1, Jak2 and Tyk2 in human liver. Although experiments in vitro indicate that Jak2 mediates GH signalling, our results open the possibility that other Jak proteins may influence GHR signalling in human liver.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Jak2Ratgrowth hormone receptor binding enablesIPIUniProtKB:P10912PMID:10502458BHF-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Jak2  (Janus kinase 2)


Additional Information