RGD Reference Report - Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. - Rat Genome Database

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Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences.

Authors: Goldschmidt-Reisin, S  Kitakawa, M  Herfurth, E  Wittmann-Liebold, B  Grohmann, L  Graack, HR 
Citation: Goldschmidt-Reisin S, etal., J Biol Chem. 1998 Dec 25;273(52):34828-36.
RGD ID: 8553474
Pubmed: PMID:9857009   (View Abstract at PubMed)

The integrity of healthy mitochondria is supposed to depend largely on proper mitochondrial protein biosynthesis. Mitochondrial ribosomal proteins (MRPs) are directly involved in this process. To identify mammalian mitochondrial ribosomal proteins and their corresponding genes, we purified mature rat MRPs and determined 12 different N-terminal amino acid sequences. Using this peptide information, data banks were screened for corresponding DNA sequences to identify the genes or to establish consensus cDNAs and to characterize the deduced MRP open reading frames. Eight different groups of corresponding mammalian MRPs constituted from human, mouse, and rat origin were identified. Five of them show significant sequence similarities to bacterial and/or yeast mitochondrial ribosomal proteins. However, MRPs are much less conserved in respect to the amino acid sequence among species than cytoplasmic ribosomal proteins of eukaryotes and bacteria.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Mrpl40Ratmitochondrial ribosome located_inIDA PMID:9857009UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Mrpl40  (mitochondrial ribosomal protein L40)


Additional Information