RGD Reference Report - High-flow-induced arterial remodeling in rats with different susceptibilities to cerebral aneurysms. - Rat Genome Database

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High-flow-induced arterial remodeling in rats with different susceptibilities to cerebral aneurysms.

Authors: Coutard, M  Osborne-Pellegrin, M  Fontaine, V  Jacob, MP  Michel, JB 
Citation: Coutard M, etal., J Vasc Res. 2006;43(3):217-28. Epub 2006 Jan 20.
RGD ID: 8552771
Pubmed: PMID:16428894   (View Abstract at PubMed)
DOI: DOI:10.1159/000091101   (Journal Full-text)

BACKGROUND: The higher incidence of cerebral aneurysms (CAs) induced by enhanced arterial blood flow in Long Evans (LE) compared to Brown Norway (BN) rats suggests that intrinsic differences in high-flow arterial remodeling may be involved in determining CA susceptibility. Some aspects of this remodeling were compared in LE and BN rats after creation of an abdominal aortocaval fistula (ACF). METHODS AND RESULTS: At 4 days with ACF, aortic luminal cross-sectional area (LCSA) determined by morphometry was increased by 20% in LE but not in BN rats. mRNA levels, determined by RT-PCR, were higher in LE than in BN rats for collagen alpha1(I), collagen alpha1(III), MMP2 and its inhibitor TIMP1 at 19 days with ACF. Nitric oxide synthase (NOS) mRNA levels were higher in LE rats at 4 days for the inducible (NOS2) isoform and at 4 and 19 days for the neuronal (NOS1) isoform. Aortic LCSA and NOS1 mRNA levels were tightly correlated and NOS inhibition prevented ACF-induced aortic remodeling in the LE rat. MMP2 and MMP7 activity, evaluated by zymography at 4 days with ACF, did not greatly differ between BN and LE. CONCLUSIONS: These data suggest that a higher intrinsic ability for high-flow-induced arterial enlargement associated with NOS gene overexpression may be a possible genetic determinant in CA susceptibility.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
COL1A1HumanArteriovenous Fistula  ISOCol1a1 (Rattus norvegicus)in Long Evans rats and mRNA:increased expression:aortaRGD 
Col1a1RatArteriovenous Fistula  IEP in Long Evans rats and mRNA:increased expression:aortaRGD 
Col1a1MouseArteriovenous Fistula  ISOCol1a1 (Rattus norvegicus)in Long Evans rats and mRNA:increased expression:aortaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Col1a1  (collagen type I alpha 1 chain)

Genes (Mus musculus)
Col1a1  (collagen, type I, alpha 1)

Genes (Homo sapiens)
COL1A1  (collagen type I alpha 1 chain)


Additional Information